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Case Reports
. 2020 Aug 25:34:100631.
doi: 10.1016/j.gore.2020.100631. eCollection 2020 Nov.

Neoadjuvant chemotherapy with paclitaxel/carboplatin/bevacizumab in advanced vulvar cancer: Time to rethink standard of care?

Madison R Klavans  1 , Sarah H Erickson  2 , Susan C Modesitt  1   3
Affiliations
Case Reports

Neoadjuvant chemotherapy with paclitaxel/carboplatin/bevacizumab in advanced vulvar cancer: Time to rethink standard of care?

Madison R Klavans et al. Gynecol Oncol Rep. .

Abstract

Vulvar cancer remains a rare entity and treatment options for advanced disease are limited. This case report highlights the excellent response of two patients with FIGO Stage IV vulvar cancer treated with neoadjuvant paclitaxel/carboplatin/bevacizumab chemotherapy. While definitive conclusions are impossible, neoadjuvant chemotherapy may ultimately prove to be a better initial treatment option for locally advanced disease in terms of quality of life and response compared to the traditional chemoradiation regimens.

Keywords: Advanced vulvar cancer; Bevacizumab; Carboplatin; Neoadjuvant therapy; Paclitaxel.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1A
Fig. 1A
Case 1: Large exophytic vulvar lesion on initial presentation.
Fig. 1B
Fig. 1B
Same lesion following two cycles of neoadjuvant chemotherapy.
Fig. 1C
Fig. 1C
At the completion of six cycles.
Fig. 2A
Fig. 2A
Axial image from CT chest from the patient in case 1 on initial presentation demonstrating the largest pulmonary nodule measuring 14 mm diameter in the right lower lobe.
Fig. 2B
Fig. 2B
Axial image from CT chest following six cycles of paclitaxel/carboplatin/bevacizumab, demonstrating near complete interval resolution of the same right lower lobe nodule.
Fig. 3A
Fig. 3A
Case 2: Initial presentation with necrotic vulvar lesion encompassing the labia, mons, clitoris and perineum.
Fig. 3B
Fig. 3B
Following two cycles of neoadjuvant chemotherapy.
See this image and copyright information in PMC

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