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. 2020 Sep 15;4(1):e000740.
doi: 10.1136/bmjpo-2020-000740. eCollection 2020.

Comparison of neonatal outcomes of small for gestational age and appropriate for gestational age preterm infants born at 28-36 weeks of gestation: a multicentre study in Ethiopia

Netsanet Workneh Gidi  1   2 , Robert L Goldenberg  3 , Assaye K Nigussie  4 , Elizabeth McClure  5 , Amha Mekasha  6 , Bogale Worku  6   7 , Matthias Siebeck  8 , Orsolya Genzel-Boroviczeny  9 , Lulu M Muhe  6
Affiliations

Comparison of neonatal outcomes of small for gestational age and appropriate for gestational age preterm infants born at 28-36 weeks of gestation: a multicentre study in Ethiopia

Netsanet Workneh Gidi et al. BMJ Paediatr Open. .

Abstract

Purpose: The aim of this study was to assess morbidity and mortality pattern of small for gestational age (SGA) preterm infants in comparison to appropriate for gestational age (AGA) preterm infants of similar gestational age.

Method: We compared neonatal outcomes of 1336, 1:1 matched, singleton SGA and AGA preterm infants based on their gestational age using data from the study 'Causes of Illness and Death of Preterm Infants in Ethiopia (SIP)'. Data were analysed using SPSS V.23. ORs and 95% CIs and χ2 tests were done, p value of <0.05 was considered statistically significant.

Result: The majority of the infants (1194, 89%) were moderate to late preterm (32-36 weeks of gestation), 763 (57%) were females. Male preterm infants had higher risk of being SGA than female infants (p<0.001). SGA infants had increased risk of hypoglycaemic (OR and 95% CI 1.6 (1.2 to 2.0), necrotising enterocolitis (NEC) 2.3 (1.2 to 4.1), polycythaemia 3.0 (1.6 to 5.4), late-onset neonatal sepsis (LOS) 3.6 (1.1 to 10.9)) and prolonged hospitalisation 2.9 (2.0 to 4.2). The rates of respiratory distress syndrome (RDS), apnoea and mortality were similar in the SGA and AGA groups.

Conclusion: Neonatal complications such as hypoglycaemic, NEC, LOS, polycythaemia and prolonged hospitalisation are more common in SGA infants, while rates of RDS and mortality are similar in SGA and AGA groups. Early recognition of SGA status, high index of suspicion and screening for complications associated and timely intervention to prevent complications need due consideration.

Keywords: mortality; neonatology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
A total of 1336 singleton SGA and AGA preterm infants were eligible for the study. AGA, appropriate for gestational age; NICU, neonatal intensive care unit; SGA, small for gestational age; SIP, Causes of Illness and Death of Preterm Infants in Ethiopia.
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