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Comparative Study
. 1987 Jun;55(2):322-7.

Activity of selected beta-lactam antibiotics against Mycobacterium leprae

C C Shepard, R M Van Landingham, L L Walker, R C Good
  • PMID: 3298478
Comparative Study

Activity of selected beta-lactam antibiotics against Mycobacterium leprae

C C Shepard et al. Int J Lepr Other Mycobact Dis. 1987 Jun.

Abstract

Twelve beta-lactam antibiotics were tested for activity against Mycobacterium leprae growing in the foot pads of mice. Two cephalosporins (7-aminocephalosporanic acid and cefuroxime) and one cephamycin (cefoxitin) showed significant activity against M. leprae, and one penicillin (mezlocillin) exerted possible growth-promoting activity. These results suggest that particular molecular structures may be required for activity against M. leprae.

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