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. 1987 Jul 1;166(1):219-34.
doi: 10.1084/jem.166.1.219.

Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer

P W Kantoff, A P Gillio, J R McLachlin, C Bordignon, M A Eglitis, N A Kernan, R C Moen, D B Kohn, S F Yu, E Karson, et al.

Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer

P W Kantoff et al. J Exp Med. .

Abstract

Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.

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References

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