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. 2020 Sep-Oct;17(9):1479164120958625.
doi: 10.1177/1479164120958625.

High hemoglobin glycation index is associated with increased systemic arterial stiffness independent of hyperglycemia in real-world Japanese population: A cross-sectional study

Daiji Nagayama  1 , Yasuhiro Watanabe  2 , Takashi Yamaguchi  2 , Atsuhito Saiki  2 , Kohji Shirai  3 , Ichiro Tatsuno  2
Affiliations

High hemoglobin glycation index is associated with increased systemic arterial stiffness independent of hyperglycemia in real-world Japanese population: A cross-sectional study

Daiji Nagayama et al. Diab Vasc Dis Res. 2020 Sep-Oct.

Abstract

Aims: To investigate the association of metabolic parameters including hemoglobin glycation index (HGI, observed HbA1c - predicted HbA1c) with systemic arterial stiffness assessed by cardio-ankle vascular index (CAVI).

Subjects: We analyzed the cross-sectional data from 22,696 subjects (mean age 48.0 years, mean FPG 88 mg/dL, mean HbA1c 5.5%) with or without past history of metabolic disorders including diabetes.

Results: Men had higher body mass index (BMI), CAVI, blood pressure (BP), FPG, HbA1c, total cholesterol and triglyceride; and lower age, HGI and HDL-cholesterol. After stratifying subjects into HGI quartiles, the highest quartile (Q4) group showed higher age, female ratio, and frequencies of obesity, hypertension, diabetes, and dyslipidemia. Furthermore, bivariate logistic regression model revealed that the Q4 of HGI was a significant predictor of high CAVI (⩾9.0) independent of the presence of diabetes.

Conclusion: High HGI is associated with systemic arterial stiffening independent of hyperglycemia. This index is therefore expected to be not only a predictor of hypoglycemia, but also a therapeutic guide for atherosclerosis.

Keywords: Glycemic parameters; arterial stiffness; cardio-ankle vascular index; hemoglobin glycation index.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Correlation of HGI with HbA1c. The scatter plot shows the distribution of HGI with HbA1c. HGI: hemoglobin glycation index; HbA1c: glycated hemoglobin.
See this image and copyright information in PMC

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