Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Nov 1;180(11):1546-1549.
doi: 10.1001/jamainternmed.2020.5084.

The Exclusion of Older Persons From Vaccine and Treatment Trials for Coronavirus Disease 2019-Missing the Target

Benjamin K I Helfand  1   2 , Margaret Webb  3 , Sarah L Gartaganis  3 , Lily Fuller  3 , Churl-Su Kwon  4 , Sharon K Inouye  3
Affiliations

The Exclusion of Older Persons From Vaccine and Treatment Trials for Coronavirus Disease 2019-Missing the Target

Benjamin K I Helfand et al. JAMA Intern Med. .

Abstract

This cross-sectional study evaluates the risk of exclusion for older adults in randomized clinical trials for treatment and vaccine interventions in coronavirus disease 2019.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: None reported.

References

    1. United Nations, Department of Economic and Social Affairs Population Dynamics Data Query: Population by age and sex (thousands). United Nations, Department of Economic and Social Affairs Population Dynamics. https://population.un.org/wpp/DataQuery/. Published 2020. Accessed June 18, 2020.
    1. Centers for Disease Control and Prevention Cases and Deaths in the U.S. https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/us-cases-deaths..... Published 2020. Updated June 24, 2020. Accessed June 25, 2020.
    1. Bernard MA, Clayton JA, Lauer MS. Inclusion across the lifespan: NIH policy for clinical research. JAMA. 2018;320(15):1535-1536. doi:10.1001/jama.2018.12368 - DOI - PubMed
    1. Boulware DR, Pullen MF, Bangdiwala AS, et al. . A randomized trial of hydroxychloroquine as postexposure prophylaxis for Covid-19. N Engl J Med. 2020;383(6):517-525. doi:10.1056/NEJMoa2016638 - DOI - PMC - PubMed
    1. Ciabattini A, Nardini C, Santoro F, Garagnani P, Franceschi C, Medaglini D. Vaccination in the elderly: the challenge of immune changes with aging. Semin Immunol. 2018;40:83-94. - PubMed

Publication types

MeSH terms

Substances