Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Jan;41(1):217-220.
doi: 10.1007/s10875-020-00870-y. Epub 2020 Sep 28.

Unusual Prominent Pulmonary Involvement in a Homozygous PRF1 Gene Variant in a Female Patient

Fahad Alsohime  1 , Talal Almaghamsi  2 , Talal A Basha  3 , Hosam Alardati  4 , Malak Alghamdi  5 , Yousef Mohammed Hawsawi  6   7   8
Affiliations
Case Reports

Unusual Prominent Pulmonary Involvement in a Homozygous PRF1 Gene Variant in a Female Patient

Fahad Alsohime et al. J Clin Immunol. 2021 Jan.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
a Axial chest computed tomography scan in the lung window demonstrates extensive bilateral asymmetric areas of peripheral air space consolidation with associated air bronchograms and b CT scan showed interval development of scattered bilateral thin-walled cysts, with no lobe predominance
Fig. 2
Fig. 2
There is diffuse interstitial lymphocytic infiltrate of small lymphocytes with widening of the alveolar septa and hyperplasia of type 2 pneumocytes. The inflammatory infiltrate also includes macrophages and few neutrophils. (hematoxylin and eosin stain; 400x magnification)
See this image and copyright information in PMC

References

    1. Campo E, Harris NL. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: International Agency for Research on Cancer; 2017.
    1. Stepp SE, Dufourcq-Lagelouse R, Le Deist F, Bhawan S, Certain S, Mathew PA, et al. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science. 1999;286:1957–1959. doi: 10.1126/science.286.5446.1957. - DOI - PubMed
    1. Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48(2):124–131. doi: 10.1002/pbc.21039. - DOI - PubMed
    1. Seguin A, Galicier L, Boutboul D, Lemiale V, Azoulay E. Pulmonary involvement in patients with hemophagocytic lymphohistiocytosis. Chest. 2016;149:1294–1301. doi: 10.1016/j.chest.2015.11.004. - DOI - PubMed
    1. Kim R, Meyer KC. Therapies for interstitial lung disease: past, present and future. Ther Adv Respir Dis. 2008;2:319–338. doi: 10.1177/1753465808096948. - DOI - PubMed