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Case Reports
. 2021 Oct 5;73(7):e1762-e1765.
doi: 10.1093/cid/ciaa1474.

Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019

Martin Martinot  1 , Aude Jary  2 , Samira Fafi-Kremer  3   4 , Valentin Leducq  2 , Heloise Delagreverie  3   4 , Marc Garnier  5 , Jérôme Pacanowski  6 , Arsène Mékinian  7 , France Pirenne  8   9 , Pierre Tiberghien  8   10 , Vincent Calvez  2 , Catherine Humbrecht  11 , Anne-Geneviève Marcelin  2 , Karine Lacombe  12
Affiliations
Case Reports

Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019

Martin Martinot et al. Clin Infect Dis. .

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.

Keywords: COVID-19; RNA-dependent RNA-polymerase mutation; SARS-CoV-2; convalescent plasma; remdesivir.

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