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Review
. 2020 Sep 24;21(19):7038.
doi: 10.3390/ijms21197038.

Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair

Parinaz Ahangar  1   2 , Stuart J Mills  1 , Allison J Cowin  1
Affiliations
Review

Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair

Parinaz Ahangar et al. Int J Mol Sci. .

Abstract

The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cytokines, referred to as the MSC secretome, that has considerable potential for the treatment of cutaneous wounds as a cell-free therapy. In this review, we outline the current status of MSCs as a treatment for cutaneous wounds and introduce the potential of the MSC secretome as a cell-free alternative for wound repair. We discuss the challenges and provide insights and perspectives for the future development of the MSC secretome as well as identify its potential clinical translation into a therapeutic treatment.

Keywords: mesenchymal stem cells; secretome; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Mechanisms of mesenchymal stem cells secretome on the wound healing process.
See this image and copyright information in PMC

References

    1. Ahangar P., Woodward M., Cowin A.J. Advanced wound therapies. Wound Pract. Res. 2018;26:58–68.
    1. Gonzalez A.C.D.O., Freire T.F.C., Andrade Z.D.A., Medrado A.P. Wound healing—A literature review. An. Bras. Dermatol. 2016;91:614–620. doi: 10.1590/abd1806-4841.20164741. - DOI - PMC - PubMed
    1. Han G., Ceilley R. Chronic wound healing: A review of current management and treatments. Adv. Ther. 2017;34:599–610. doi: 10.1007/s12325-017-0478-y. - DOI - PMC - PubMed
    1. Johnson R.M., Richard R. Partial-thickness burns: Identification and management. Adv. Skin Wound Care. 2003;16:178–187. - PubMed
    1. Simpson D., Liu H., Fan T.H.M., Nerem R., Dudley S.C., Jr. A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling. Stem Cells. 2007;25:2350–2357. doi: 10.1634/stemcells.2007-0132. - DOI - PMC - PubMed

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