Reply to Yan and Muller, "Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity"

Minh Patrick Lê^{1

2}, Christine Le Beller³, Quentin Le Hingrat^{4

5}, Pierre Jaquet⁶, Paul-Henri Wicky⁷, Vincent Bunel⁷, Laurent Massias^{8

5}, Benoit Visseaux^{4

5}, Jonathan Messika⁷, Diane Descamps^{4

5}, Hervé Mal⁷, Jean-François Timsit^{5

6}, Gilles Peytavin^{8

5}

Affiliations

¹ AP-HP, Bichat Claude Bernard Hospital, Pharmacology-Toxicology Department, Paris, France minh.le@aphp.fr.
² INSERM, UMRS-1144, Université de Paris, Paris, France.
³ AP-HP, Hôpital Européen Georges Pompidou, Centre Régional de Pharmacovigilance, Paris, France.
⁴ AP-HP, Bichat Claude Bernard Hospital, Virology Department, Paris, France.
⁵ IAME, INSERM, UMRS1137, Université de Paris, Paris, France.
⁶ AP-HP, Bichat Claude Bernard Hospital, Medical and Infectious Diseases ICU (MI2), Paris, France.
⁷ AP-HP, Bichat Claude Bernard Hospital, Pneumology B and Lung Transplant Department, INSERM 1152, Paris Transplant Group, Paris, France.
⁸ AP-HP, Bichat Claude Bernard Hospital, Pharmacology-Toxicology Department, Paris, France.

Comment

Minh Patrick Lê et al. Antimicrob Agents Chemother. 2020.

. 2020 Nov 17;64(12):e01937-20.

doi: 10.1128/AAC.01937-20. Print 2020 Nov 17.

¹ AP-HP, Bichat Claude Bernard Hospital, Pharmacology-Toxicology Department, Paris, France minh.le@aphp.fr.
² INSERM, UMRS-1144, Université de Paris, Paris, France.
³ AP-HP, Hôpital Européen Georges Pompidou, Centre Régional de Pharmacovigilance, Paris, France.
⁴ AP-HP, Bichat Claude Bernard Hospital, Virology Department, Paris, France.
⁵ IAME, INSERM, UMRS1137, Université de Paris, Paris, France.
⁶ AP-HP, Bichat Claude Bernard Hospital, Medical and Infectious Diseases ICU (MI2), Paris, France.
⁷ AP-HP, Bichat Claude Bernard Hospital, Pneumology B and Lung Transplant Department, INSERM 1152, Paris Transplant Group, Paris, France.
⁸ AP-HP, Bichat Claude Bernard Hospital, Pharmacology-Toxicology Department, Paris, France.

No abstract available

Comment on

Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19.
Lê MP, Le Hingrat Q, Jaquet P, Wicky PH, Bunel V, Massias L, Visseaux B, Messika J, Descamps D, Mal H, Timsit JF, Peytavin G. Lê MP, et al. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01521-20. doi: 10.1128/AAC.01521-20. Print 2020 Oct 20. Antimicrob Agents Chemother. 2020. PMID: 32868327 Free PMC article.
Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity.
Yan VC, Muller FL. Yan VC, et al. Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01920-20. doi: 10.1128/AAC.01920-20. Print 2020 Nov 17. Antimicrob Agents Chemother. 2020. PMID: 32988821 Free PMC article. No abstract available.

1. Yan VC, Muller FL. 2020. Captisol and GS-704277, but not GS-441524, are credible mediators of remdesivir’s nephrotoxicity. Antimicrob Agents Chemother 64:e01920-20. doi:10.1128/AAC.01920-20. - DOI - PMC - PubMed
1. Lê MP, Le Hingrat Q, Jaquet P, Wicky P-H, Bunel V, Massias L, Visseaux B, Messika J, Descamps D, Mal H, Timsit J-F, Peytavin G. 31 August 2020. Removal of remdesivir’s metabolite GS-441524 by hemodialysis in a double lung transplant recipient with COVID-19. Antimicrob Agents Chemother doi:10.1128/AAC.01521-20. - DOI - PMC - PubMed
1. Murthy S, Gomersall CD, Fowler RA. 2020. Care for critically ill patients with COVID-19. JAMA 323:1499. doi:10.1001/jama.2020.3633. - DOI - PubMed
1. Soleimani M. 2020. Acute kidney injury in SARS-CoV-2 infection: direct effect of virus on kidney proximal tubule cells. Int J Mol Sci 21:3275. doi:10.3390/ijms21093275. - DOI - PMC - PubMed
1. Fanelli V, Fiorentino M, Cantaluppi V, Gesualdo L, Stallone G, Ronco C, Castellano G. 2020. Acute kidney injury in SARS-CoV-2 infected patients. Crit Care 24:155. doi:10.1186/s13054-020-02872-z. - DOI - PMC - PubMed