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. 2020 Oct 1;33(4):326-334.
doi: 10.3344/kjp.2020.33.4.326.

Effect of intraperitoneally administered propentofylline in a rat model of postoperative pain

Geun Joo Choi  1 , Hyun Kang  1 , Jun Mo Lee  1 , Chong Wha Baek  1 , Yong Hun Jung  1 , Young Cheol Woo  1 , Jae Hyuk Do  2 , Jin Soo Ko  3
Affiliations

Effect of intraperitoneally administered propentofylline in a rat model of postoperative pain

Geun Joo Choi et al. Korean J Pain. .

Abstract

Background: In this study, we sought to evaluate whether systemic propentofylline (PPF) has antiallodynic effects in a rat model of postoperative pain, and to assess the mechanism involved.

Methods: After plantar incision, rats were intraperitoneally injected with various doses of PPF to evaluate its antiallodynic effect. To investigate the involved mechanism, rats were intraperitoneally injected with yohimbine, dexmedetomidine, prazosin, naloxone, atropine or mecamylamine, following the incision of the rat hind paws, and then PPF was administered intraperitoneally. The mechanical withdrawal threshold (MWT) was evaluated using von Frey filaments at various time points and serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were measured to determine the inflammatory response level.

Results: MWT was significantly increased after intraperitoneal injection of 30 mg/kg of PPF when compared with the control group. Injection of PPF and yohimbine, atropine or mecamylamine showed significant decreases in the MWT, while injection of PPF and dexmedetomidine showed a significant increase. Systemic administration of PPF inhibited the post-incisional increase in serum level of TNF-α and IL-1β.

Conclusions: Systemic administration of PPF following surgery presented antiallodynic effects in a rat model of postoperative pain. The antiallodynic effects against mechanical allodynia could be mediated by α-adrenergic and cholinergic receptors.

Keywords: Acute pain; Animals; Hyperalgesia; Injections; Intraperitoneal; Pain; Pain Management; Postoperative; Propentofylline; Rats.

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Conflict of interest statement

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
Antiallodynic effect of post-incisional-administered propentofylline (PPF). BL: baseline, AI: after incision. *P < 0.05 compared with the control group.
Fig. 2
Fig. 2
Antiallodynic mechanisms of propentofylline (PPF) with (A) dexmedetomidine, yohimbine or prazosin and (B) naloxone, mecamylamine or atropine. BL: baseline, AI: after incision. *P < 0.05 compared with the PPF 30 mg/kg group.
Fig. 3
Fig. 3
Effects of propentofylline (PPF) on Rotarod testing. BL: baseline.
Fig. 4
Fig. 4
Effect of propentofylline (PPF) on the plasma concentration of (A) tumor necrosis factor (TNF)-α, (B) interleukin (IL)-1β (C) and IL-6. *P < 0.05 compared with control group.
Fig. 5
Fig. 5
Antiallodynic effect of propentofylline (PPF) 30 mg/kg compared with ketorolac 30 mg/kg and control group. BL: baseline, AI: after incision. *P < 0.05 compared with control group, †P < 0.05 compared with PPF 30 mg/kg group.
Fig. 6
Fig. 6
Area under curve for mechanical withdrawal threshold for the comparison of propentofylline (PPF) 30 mg/kg, ketorolac 30 mg/kg and control group. *P < 0.05 compared with control group.
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