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. 2020 Dec;99(12):2831-2836.
doi: 10.1007/s00277-020-04284-z. Epub 2020 Sep 28.

Long-term follow-up of abbreviated R-CHOP chemoimmunotherapy for completely resected limited-stage diffuse large B cell lymphoma (CISL 12-09)

Sora Kang  1 , Hyungwoo Cho  2 , Byeong Seok Sohn  3 , Sung Yong Oh  4 , Won-Sik Lee  5 , Sang Min Lee  5 , Deok-Hwan Yang  6 , Jooryung Huh  7 , Dok Hyun Yoon  8 , Cheolwon Suh  9
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Long-term follow-up of abbreviated R-CHOP chemoimmunotherapy for completely resected limited-stage diffuse large B cell lymphoma (CISL 12-09)

Sora Kang et al. Ann Hematol. 2020 Dec.

Abstract

The standard of treatment for completely resected limited-stage diffuse large B cell lymphoma (DLBCL) in patients without residual lesions has not yet been established. Previously, we designed a phase II trial to evaluate the safety and efficacy of three cycles of abbreviated R-CHOP in patients with completely resected limited-stage DLBCL and reported favorable survival outcomes. We present the long-term follow-up results to taking into account the importance of delayed relapse in patients with limited-stage DLBCL. With a median follow-up duration of 62.7 months (range, 60.2-75.5 months), the 5-year OS and DFS rates were both 95.0% (95% confidence interval, 85.59-104.11%). Only one patient experienced disease progression which was confirmed at 12.3 months, and one patient with primary intestinal DLBCL developed non-small cell lung cancer 6 years after treatment. The long-term results of our data support the use of three cycles of abbreviated R-CHOP for patients with completely resected limited-stage DLBCL. The study was reviewed and approved by the review boards of the participating institutes and registered at ClinicalTrials.gov , number NCT01279902, in August 3, 2010.

Keywords: Complete resection; Diffuse large B cell lymphoma; Limited stage; R-CHOP.

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