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. 2021 Mar;85(3):1441-1454.
doi: 10.1002/mrm.28527. Epub 2020 Sep 28.

Distortion-free 3D diffusion imaging of the prostate using a multishot diffusion-prepared phase-cycled acquisition and dictionary matching

Elisa Roccia  1 , Radhouene Neji  1   2 , Thomas Benkert  3 , Berthold Kiefer  3 , Vicky Goh  1   4 , Isabel Dregely  1
Affiliations

Distortion-free 3D diffusion imaging of the prostate using a multishot diffusion-prepared phase-cycled acquisition and dictionary matching

Elisa Roccia et al. Magn Reson Med. 2021 Mar.

Abstract

Purpose: To achieve three-dimensional (3D) distortion-free apparent diffusion coefficient (ADC) maps for prostate imaging using a multishot diffusion prepared-gradient echo (msDP-GRE) sequence and ADC dictionary matching.

Methods: The msDP-GRE sequence is combined with a 3D Cartesian, centric k-space trajectory with center oversampling. Oversampled k-space center averaging and phase cycling are used to address motion- and eddy current-induced magnitude corruption. Extended-phase-graph (EPG) simulations and ADC dictionary matching are used to compensate for T1 effects. To shorten the acquisition time, each volume is undersampled by a factor of two and reconstructed using iterative sensitivity encoding. The proposed approach is characterized using simulations and validated in a kiwifruit phantom, comparing the msDP-GRE ADC maps obtained using both standard monoexponential fitting and dictionary matching with the clinical standard single-shot diffusion weighted-echo planar imaging (ssDW-EPI) ADC. Initial in vivo feasibility is tested in three healthy subjects, and geometric distortion is compared with anatomical T2 -weighted-turbo spin echo.

Results: In the kiwifruit phantom experiment, the signal magnitude could be recovered using k-space center averaging and phase cycling. No statistically significant difference was observed in the ADC values estimated using msDP-GRE with dictionary matching and clinical standard DW-EPI (P < .05). The in vivo prostate msDP-GRE scans were free of geometric distortion caused by off-resonance susceptibility, and the ADC values in the prostate were in agreement with values found in the published literature.

Conclusion: Nondistorted 3D ADC maps of the prostate can be achieved using a msDP sequence and dictionary matching.

Keywords: 3T magnetic resonance imaging; apparent diffusion coefficient mapping; dictionary matching; diffusion; prostate cancer imaging; quantitative magnetic resonance imaging.

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