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. 2020 Sep 29;72(1):66.
doi: 10.1186/s43044-020-00101-0.

Prevalence of type 2 diabetes mellitus and association of HbA1c with severity of coronary artery disease in patients presenting as non-diabetic acute coronary syndrome

Mohd Iqbal Dar  1 , Jahangir Rashid Beig  2 , Iqra Jan  3 , Tariq Rashid Shah  2 , Muzaffar Ali  2 , Hilal A Rather  2 , Nisar A Tramboo  2
Affiliations

Prevalence of type 2 diabetes mellitus and association of HbA1c with severity of coronary artery disease in patients presenting as non-diabetic acute coronary syndrome

Mohd Iqbal Dar et al. Egypt Heart J. .

Abstract

Background: Acute coronary syndrome (ACS) indicates the serious clinical manifestation of coronary artery disease (CAD) and is closely associated with cardiovascular prognosis in patients with ACS. This study was aimed to study the prevalence of type 2 diabetes mellitus (T2DM) and the relation of HbA1c with the severity of CAD in patients presenting as non-diabetic ACS. Diabetic status of the patients was assessed with fasting blood sugar (FBS) and HbA1c levels, and coronary artery disease burden was assessed by coronary angiography.

Results: Out of 208 patients, 85.1% were males, and 14.9% were females; 73.56% cases were hypertensive. 80.77% of cases had STEMI, 17.79% had NSTEMI, and 1.44% had unstable angina. Out of 168 STEMI patients, 64.3% were thrombolysed, 21.42% presented late, 2.38% had contraindications to thrombolysis, and 11.9% underwent primary PCI. FBS in diabetic range was found in 44.23% of cases, impaired FBS in 36.54%, and 19.23% of patients had FBS in non-diabetic range. According to HbA1c, 41.8% were diabetic, 39.4% were pre-diabetic, and 18.8% were non-diabetic. A significant positive correlation was found between HbA1c and Gensini score and between HbA1c and the number of vessels involved.

Conclusion: This study emphasises the importance of evaluating the presence of diabetes in patients presenting as non-diabetic acute coronary syndrome in developing countries. Acute coronary syndrome may be considered as one of the presentations of diabetes mellitus.

Keywords: Acute coronary syndrome; Coronary angiography; Diabetes; HbA1c.

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Conflict of interest statement

Nothing to declare

Figures

Fig. 1
Fig. 1
Calculation of Gensini score [7]
Fig. 2
Fig. 2
Fasting blood sugar levels
Fig. 3
Fig. 3
HbA1c levels of the study population
Fig. 4
Fig. 4
Scatter plot showing correlation between HbA1c and Gensini score of the study
See this image and copyright information in PMC

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