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. 2021 Aug;15(4):1986-1996.
doi: 10.1007/s11682-020-00392-6. Epub 2020 Sep 29.

The exploration of Parkinson's disease: a multi-modal data analysis of resting functional magnetic resonance imaging and gene data

Xia-An Bi  1   2 , Hao Wu  3   4 , Yiming Xie  3   4 , Lixia Zhang  3   4 , Xun Luo  3   4 , Yu Fu  3   4 ; Alzheimer’s Disease Neuroimaging Initiative
Affiliations

The exploration of Parkinson's disease: a multi-modal data analysis of resting functional magnetic resonance imaging and gene data

Xia-An Bi et al. Brain Imaging Behav. 2021 Aug.

Abstract

Parkinson's disease (PD) is the most universal chronic degenerative neurological dyskinesia and an important threat to elderly health. At present, the researches of PD are mainly based on single-modal data analysis, while the fusion research of multi-modal data may provide more meaningful information in the aspect of comprehending the pathogenesis of PD. In this paper, 104 samples having resting functional magnetic resonance imaging (rfMRI) and gene data are from Parkinson's Progression Markers Initiative (PPMI) and Alzheimer's Disease Neuroimaging Initiative (ADNI) database to predict pathological brain areas and risk genes related to PD. In the experiment, Pearson correlation analysis is adopted to conduct fusion analysis from the data of genes and brain areas as multi-modal sample characteristics, and the clustering evolution random forest (CERF) method is applied to detect the discriminative genes and brain areas. The experimental results indicate that compared with several existing advanced methods, the CERF method can further improve the diagnosis of PD and healthy control, and can achieve a significant effect. More importantly, we find that there are some interesting associations between brain areas and genes in PD patients. Based on these associations, we notice that PD-related brain areas include angular gyrus, thalamus, posterior cingulate gyrus and paracentral lobule, and risk genes mainly include C6orf10, HLA-DPB1 and HLA-DOA. These discoveries have a significant contribution to the early prevention and clinical treatments of PD.

Keywords: Clustering evolution random forest; Multi-modal data fusion; Parkinson’s disease; RfMRI; SNP.

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