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Review
. 2020 Oct;49(9):1123-1130.
doi: 10.1097/MPA.0000000000001658.

Differential Diagnosis of Diarrhea in Patients With Neuroendocrine Tumors

Jennifer R Eads  1 , Diane Reidy-Lagunes  2 , Heloisa P Soares  3 , Jennifer A Chan  4 , Lowell B Anthony  5 , Thorvardur R Halfdanarson  6 , Boris G Naraev  7 , Edward M Wolin  8 , Daniel M Halperin  9 , Daneng Li  10 , Rodney F Pommier  11 , Jerome S Zacks  12 , Michael A Morse  13 , David C Metz  14 ; from the Carcinoid Syndrome Control Collaborative
Affiliations
Review

Differential Diagnosis of Diarrhea in Patients With Neuroendocrine Tumors

Jennifer R Eads et al. Pancreas. 2020 Oct.

Abstract

Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience diarrhea that can have a debilitating effect on quality of life. Diarrhea also may develop in response to other hormonal syndromes associated with NETs, surgical complications, medical comorbidities, medications, or food sensitivities. Limited guidance on the practical approach to the differential diagnosis of diarrhea in these patients can lead to delays in appropriate treatment. This clinical review and commentary underscore the complexity in identifying the etiology of diarrhea in patients with NETs. Based on our collective experience and expertise, we offer a practical algorithm to guide medical oncologists and other care providers to expedite effective management of diarrhea and related symptoms in patients with NETs.

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