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Review
. 2021 Jan;28(1):59-65.
doi: 10.1097/PAP.0000000000000280.

Anti-glomerular Basement Membrane Disease: What Have We Learned?

Mohammed Akhtar  1   2 , Noheir M Taha  1   2 , Muhammad Asim  1   2
Affiliations
Review

Anti-glomerular Basement Membrane Disease: What Have We Learned?

Mohammed Akhtar et al. Adv Anat Pathol. 2021 Jan.

Abstract

Since the first clinicopathologic description by Ernest Goodpasture of a patient whom he considered to have died of influenza in 1919, substantial progress has been made in our knowledge of anti-glomerular basement membrane disease. This has led to a significant decrease in the morbidity and mortality associated with this disease. In this paper, we aim to review the literature that has enhanced our understanding of classic anti-glomerular basement membrane disease and its clinic-pathologic variants in the key areas of immunopathogenesis and histopathology. We also summarize varied clinical presentations and therapeutic strategies.

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References

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    1. Goodpasture E. The significance of certain pulmonary lesions in relation to the etiology of influenza. Am J Med Sci. 1919;158:863–870.
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