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Editorial
. 2021 Apr;109(4):689-691.
doi: 10.1002/JLB.3CE0720-468. Epub 2020 Sep 29.

Reversal of sepsis-induced T cell dysfunction: OX-40 to the rescue?

Edward R Sherwood  1   2 , David L Williams  2   3
Affiliations
Editorial

Reversal of sepsis-induced T cell dysfunction: OX-40 to the rescue?

Edward R Sherwood et al. J Leukoc Biol. 2021 Apr.

Abstract

The study of Unsinger and colleagues provide important insights into OX40 mediated immunotherapy as a potential approach for the treatment of sepsis induced immune suppression.

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Conflict of interest statement

DISCLOSURES

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1. OX40 activation with an agonistic antibody attenuated sepsis-induced immunosuppression and improved survival outcome in a mouse model of sepsis.
In addition, the OX40 agonistic antibody increased IFN-γ expression in leukocytes from septic patients
See this image and copyright information in PMC

Comment on

References

    1. Fleischmann C, Scherag A, Adhikari NK, et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259–272. - PubMed
    1. Marshall JC. Why have clinical trials in sepsis failed?. Trends Mol Med. 2014;20(4):195–203. - PubMed
    1. Angus DC. The search for effective therapy for sepsis: back to the drawing board? JAMA. 2011;306(23):2614–2615. - PubMed
    1. Prescott HC, Osterholzer JJ, Langa KM, Angus DC, Iwashyna TJ. Late mortality after sepsis: propensity matched cohort study. BMJ. 2016;353:i2375. - PMC - PubMed
    1. Angus DC, Opal S. Immunosuppression and secondary infection in sepsis: part, not all, of the story. JAMA. 2016;315(14):1457–1459. - PubMed