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Review
. 2020 Sep 27;10(10):1373.
doi: 10.3390/biom10101373.

Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels

Trivia Frazier  1 , Andrea Alarcon  1 , Xiying Wu  1   2 , Omair A Mohiuddin  3 , Jessica M Motherwell  4 , Anders H Carlsson  5 , Robert J Christy  5 , Judson V Edwards  6 , Robert T Mackin  6 , Nicolette Prevost  6 , Elena Gloster  7 , Qiang Zhang  7 , Guangdi Wang  7 , Daniel J Hayes  8 , Jeffrey M Gimble  1   2
Affiliations
Review

Clinical Translational Potential in Skin Wound Regeneration for Adipose-Derived, Blood-Derived, and Cellulose Materials: Cells, Exosomes, and Hydrogels

Trivia Frazier et al. Biomolecules. .

Abstract

Acute and chronic skin wounds due to burns, pressure injuries, and trauma represent a substantial challenge to healthcare delivery with particular impacts on geriatric, paraplegic, and quadriplegic demographics worldwide. Nevertheless, the current standard of care relies extensively on preventive measures to mitigate pressure injury, surgical debridement, skin flap procedures, and negative pressure wound vacuum measures. This article highlights the potential of adipose-, blood-, and cellulose-derived products (cells, decellularized matrices and scaffolds, and exosome and secretome factors) as a means to address this unmet medical need. The current status of this research area is evaluated and discussed in the context of promising avenues for future discovery.

Keywords: adipose-derived stromal/stem cells (ASC); blood; burns; cellulose; exosome; platelets; pressure injury; pressure ulcer; secretome.

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Conflict of interest statement

Ms. Alarcon is an employee of Obatala Sciences. Drs. Frazier, Wu, and Gimble are co-founders, co-owners, and officers at Obatala Sciences, a biotech company focused on regenerative medicine, and are inventors of patents with technology related to the content of the manuscript. Drs. Wu and Gimble are also co-founders and co-owners of LaCell LLC and Talaria Antibodies Inc. Dr. Wang is the founder, owner, and CEO of Zenopharm LLC, a pharmaceutical discovery company. The views expressed in this article are those of the authors and do not reflect the official policy or position of the U.S. Army Medical Department, Department of the Army, DoD, or the U.S. Government. This publication was made possible by NIH Grant Number U54MD007595 from the National Institute of Minority Health and Health Disparities. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.

Figures

Figure 1
Figure 1
The processing and isolation of cells and a decellularized extracellular matrix (ECM) scaffold from adipose tissue and their application for the repair and regeneration of skin wounds.
Figure 2
Figure 2
PANTHER pathway analysis of ObaGel vs. Matrigel proteomes based on (A) >2-fold-enriched and (B) >2-fold-depleted proteins. The relative abundance of proteins in representative ObaGel and Matrigel lots was determined using TMT (Tandem Mass Tag) isobaric mass tagging using tandem mass spectrometry. Those proteins enriched > 2-fold (A) or depleted > 2-fold (B) between ObaGel and Matrigel were evaluated using PANTHER pathway analyses and plotted using a pie chart.
Figure 3
Figure 3
Computational model depicting the TEMPO-oxidized cellulose surface, featuring five parallel cellulose strands capped by methyl groups on each end. The geometry of the layer was optimized using Gaussian computational chemsitry software via semi-empirical PM3 calculation, and the colors of the atoms correspond as such—grey for carbon, red for oxygen, and black for hydrogen. The green ring highlights one of the carboxylate groups on the surface generated during the TEMPO oxidation process. This functional group is used as a chemical modification point for the nanocellulose structures.
See this image and copyright information in PMC

References

    1. Atiyeh B.S., Hayek S.N. Management of war-related burn injuries: Lessons learned from recent ongoing conflicts providing exceptional care in unusual places. J. Craniofacial Surg. 2010;21:1529–1537. doi: 10.1097/SCS.0b013e3181f3ed9c. - DOI - PubMed
    1. Tribble D.R., Krauss M.R., Murray C.K., Warkentien T.E., Lloyd B.A., Ganesan A., Greenberg L., Xu J., Li P., Carson M.L., et al. Epidemiology of Trauma-Related Infections among a Combat Casualty Cohort after Initial Hospitalization: The Trauma Infectious Disease Outcomes Study. Surg. Infect. Larchmt. 2018;19:494–503. doi: 10.1089/sur.2017.241. - DOI - PMC - PubMed
    1. Tribble D.R., Murray C.K., Lloyd B.A., Ganesan A., Mende K., Blyth D.M., Petfield J.L., McDonald J. After the Battlefield: Infectious Complications among Wounded Warriors in the Trauma Infectious Disease Outcomes Study. Mil. Med. 2019;184(Suppl. 2):18–25. doi: 10.1093/milmed/usz027. - DOI - PMC - PubMed
    1. McDonald J.R., Liang S.Y., Li P., Maalouf S., Murray C.K., Weintrob A.C., Schnaubelt E.R., Kuhn J., Ganesan A., Bradley W., et al. Infectious Complications after Deployment Trauma: Following Wounded US Military Personnel into Veterans Affairs Care. Clin. Infect. Dis. 2018;67:1205–1212. doi: 10.1093/cid/ciy280. - DOI - PMC - PubMed
    1. Weintrob A.C., Murray C.K., Xu J., Krauss M., Bradley W., Warkentien T.E., Lloyd B.A., Tribble D.R. Early Infections Complicating the Care of Combat Casualties from Iraq and Afghanistan. Surg. Infect. (Larchmt) 2018;19:286–297. doi: 10.1089/sur.2017.240. - DOI - PMC - PubMed

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