Presence of SARS-CoV-2 in urine is rare and not associated with acute kidney injury in critically ill COVID-19 patients

Robert Frithiof¹, Anders Bergqvist^{2

3}, Josef D Järhult⁴, Miklos Lipcsey^{5

6}, Michael Hultström^{5

7}

Affiliations

¹ Anesthesia and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. robert.frithiof@surgsci.uu.se.
² Clinical Microbiology and Infection Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
³ Clinical Microbiology and Hospital Infection Control, Uppsala University Hospital, Uppsala, Sweden.
⁴ Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
⁵ Anesthesia and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
⁶ Hedenstierna Laboratory, CIRRUS, Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
⁷ Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Robert Frithiof et al. Crit Care. 2020.

. 2020 Sep 29;24(1):587.

doi: 10.1186/s13054-020-03302-w.

Robert Frithiof¹, Anders Bergqvist^{2

3}, Josef D Järhult⁴, Miklos Lipcsey^{5

6}, Michael Hultström^{5

7}

¹ Anesthesia and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. robert.frithiof@surgsci.uu.se.
² Clinical Microbiology and Infection Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
³ Clinical Microbiology and Hospital Infection Control, Uppsala University Hospital, Uppsala, Sweden.
⁴ Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
⁵ Anesthesia and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
⁶ Hedenstierna Laboratory, CIRRUS, Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
⁷ Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

No abstract available

Keywords: Acute kidney injury; COVID-19; Critical illness; SARS-CoV-2; Urine.

Conflict of interest statement

The authors declare that they have no competing interests.

1. Chen YT, Shao SC, Lai EC, Hung MJ, Chen YC. Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and meta-analysis. Crit Care. 2020;24(1):439. doi: 10.1186/s13054-020-03134-8. - DOI - PMC - PubMed
1. Remmelink M, De Mendonca R, D'Haene N, De Clercq S, Verocq C, Lebrun L, Lavis P, Racu ML, Trepant AL, Maris C, et al. Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients. Crit Care. 2020;24(1):495. doi: 10.1186/s13054-020-03218-5. - DOI - PMC - PubMed
1. Bronimann S, Rebhan K, Lemberger U, Misrai V, Shariat SF, Pradere B. Secretion of severe acute respiratory syndrome coronavirus 2 in urine. Curr Opin Urol. 2020;30(5):735–739. - PMC - PubMed
1. Werion A, Belkhir L, Perrot M, Schmit G, Aydin S, Chen Z, Penaloza A, De Greef J, Yildiz H, Pothen L, et al. SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. Kidney Int. 2020. 10.1016/j.kint.2020.07.019. - PMC - PubMed
1. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, Bleicker T, Brunink S, Schneider J, Schmidt ML et al: Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25(3):1–8. - PMC - PubMed