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Review
. 2020 Sep 19:13:1179547620958728.
doi: 10.1177/1179547620958728. eCollection 2020.

Tympano-Mastoid Cholesterol Granuloma: Case Report and Review of the Literature

Annalisa Pace  1 , Giannicola Iannella  1 , Mara Riminucci  2 , Alessandro Corsi  2 , Giuseppe Magliulo  1
Affiliations
Review

Tympano-Mastoid Cholesterol Granuloma: Case Report and Review of the Literature

Annalisa Pace et al. Clin Med Insights Case Rep. .

Abstract

Cholesterol granuloma (CG) is a rare condition histological consisting of a foreign body, giant cell reaction to cholesterol crystals and haemosiderin derived from the ruptured of the erythrocytes. A 25-year-old man came to our Department presenting signs and symptoms of tympano-mastoid cholesterol granuloma. He showed all the specific sign and symptoms of the disease. However, considering the lack of literature regarding TMCG, this study was performed with the aim of presenting the main characteristics of tympano-mastoid CG, describing the case report and reviewing the literature.

Keywords: Cholesterol granuloma; cholesterol crystal; mastoid; middle ear; review.

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Conflict of interest statement

Declaration of conflicting Interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.

Figures

Figure 1.
Figure 1.
Otoscopy. Blue retrotympanic mass that involves external auditory channel.
Figure 2.
Figure 2.
Intraoperative view after the removing of tympano mastoid cholesterol granuloma (TMCG).
Figure 3.
Figure 3.
Low power magnification of the bioptic sample shows a typical cholesterol granuloma. Bar: 200 microns.
Figure 4.
Figure 4.
High power magnification of the bioptic sample highlights the clefts of cholesterol crystals (asterisks) resulting from the dissolution of cholesterol during tissue processing associated with foreign body multinucleated giant cells (arrows) and haemorrhage. Bar: 100 microns.
See this image and copyright information in PMC

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