Review

. 2020 Aug;37(4):452-467.

doi: 10.5114/ada.2020.98284. Epub 2020 Sep 2.

Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis

Agnieszka Owczarczyk-Saczonek¹, Dorota Purzycka-Bohdan², Bogusław Nedoszytko², Adam Reich³, Aneta Szczerkowska-Dobosz², Joanna Bartosiñska⁴, Aleksandra Batycka-Baran⁵, Rafał Czajkowski⁶, Iwona T Dobrucki⁷, Lawrence W Dobrucki^{7

8

9

10}, Magdalena Górecka-Sokołowska⁵, Anna Janaszak-Jasiecka⁹, Leszek Kalinowski^{9

11

12}, Dorota Krasowska⁴, Adrianna Radulska¹³, Edyta Reszka¹¹, Dominik Samotij³, Andrzej Słominski¹⁴, Radomir Słominski¹⁵, Marta Sobalska-Kwapis¹⁶, Marta Stawczyk-Macieja², Dominik Strapagiel¹⁶, Justyna Szczêch³, Michał Żmijewski¹⁷, Roman J Nowicki²

Affiliations

¹ Chair and Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
² Chair and Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.
³ Department of Dermatology, University of Rzeszow, Rzeszow, Poland.
⁴ Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.
⁵ Chair and Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
⁶ Chair and Department of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
⁷ Beckman Institute for Advanced Science and Technology, Urbana, IL, USA.
⁸ Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
⁹ Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland.
¹⁰ Biobanking and Biomolecular Resources Research Infrastructure Poland (BBMRI.PL), Gdansk, Poland.
¹¹ Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, Lodz, Poland.
¹² Gdansk University of Technology, Gdansk, Poland.
¹³ Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland.
¹⁴ Department of Dermatology, University of Alabama at Birmingham, Birmingham, USA.
¹⁵ Department of Medicine and Microbiology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA.
¹⁶ Biobank Laboratory, University of Lodz, Lodz, Poland.
¹⁷ Department of Histology, Medical University of Gdansk, Gdansk, Poland.

PMID: 32994764
PMCID: PMC7507147
DOI: 10.5114/ada.2020.98284

Review

Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis

Agnieszka Owczarczyk-Saczonek et al. Postepy Dermatol Alergol. 2020 Aug.

. 2020 Aug;37(4):452-467.

doi: 10.5114/ada.2020.98284. Epub 2020 Sep 2.

Authors

Affiliations

¹ Chair and Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
² Chair and Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.
³ Department of Dermatology, University of Rzeszow, Rzeszow, Poland.
⁴ Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.
⁵ Chair and Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
⁶ Chair and Department of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
⁷ Beckman Institute for Advanced Science and Technology, Urbana, IL, USA.
⁸ Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
⁹ Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland.
¹⁰ Biobanking and Biomolecular Resources Research Infrastructure Poland (BBMRI.PL), Gdansk, Poland.
¹¹ Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, Lodz, Poland.
¹² Gdansk University of Technology, Gdansk, Poland.
¹³ Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland.
¹⁴ Department of Dermatology, University of Alabama at Birmingham, Birmingham, USA.
¹⁵ Department of Medicine and Microbiology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA.
¹⁶ Biobank Laboratory, University of Lodz, Lodz, Poland.
¹⁷ Department of Histology, Medical University of Gdansk, Gdansk, Poland.

PMID: 32994764
PMCID: PMC7507147
DOI: 10.5114/ada.2020.98284

Abstract

Psoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and the production of inflammatory mediators involved in the development of both psoriasis and metabolic disorders. However, in psoriasis the activation of the Th17/IL-17 and the abnormalities in the Th17/Treg balance axis are observed, but this pathomechanism does not fully explain the frequent occurrence of metabolic disorders. Therefore, there is a need to look for better biomarkers in the diagnosis, prognosis and monitoring of concomitant disorders and therapeutic effects in psoriasis. In addition, the education on the use of a proper diet as a prophylaxis for the development of the above disorders is an important element of holistic care for a patient with psoriasis. Diet may affect gene expression due to epigenetic modification which encompasses interactions of environment, nutrition and diseases. Patients with psoriasis should be advised to adopt proper diet and dietician support.

Keywords: inflammation; metabolic syndrome; metabolomics; proteomic nutrigenomics; psoriasis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
An overview of the mechanism behind the “psoriatic march” [16]

**Figure 2**
The role of adipokines in psoriasis

**Figure 3**
Visceral adipose tissue endocrine function [11, 32]

**Figure 4**
Metabolomic changes in psoriasis [–76]

**Figure 5**
Proteomic changes in psoriasis [–80]

**Figure 6**
The role of micro-RNA in psoriatic skin (adapted from Kocic *et al.* [85])

See this image and copyright information in PMC

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Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis

Affiliations

Pathogenesis of psoriasis in the "omic" era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis

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