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Case Reports
. 2020 Jul 28;6(10):1039-1041.
doi: 10.1016/j.jdcr.2020.07.028. eCollection 2020 Oct.

A case of paraproteinemia-associated scleredema successfully treated with thalidomide

Affiliations
Case Reports

A case of paraproteinemia-associated scleredema successfully treated with thalidomide

Martin Barnes et al. JAAD Case Rep. .
No abstract available

Keywords: Centers for Medicare & Medicaid Services; IVIg, intravenous immunoglobulin; MGUS, monoclonal gammopathy of unknown significance; MM, multiple myeloma; PAS, paraproteinemia-associated scleredema; intravenous immunoglobulin; monoclonal gammopathy of unknown significance; multiple myeloma; paraproteinemia; paraproteinemia-associated scleredema; scleredema; thalidomide.

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Figures

Fig 1
Fig 1
Scleredema histopathologic findings. Histopathologic findings of scleredema include thickened reticular dermis and large collagen bundles separate by space containing subtle evidence of mucin (blue-grey tinge).
Fig 2
Fig 2
IgA Level (mg/dL) versus time (mos). Graph shows decrease in IgA level over time with thalidomide treatment.
Fig 3
Fig 3
Patient pictures of hands and lower extremities. Pictures of skin show woody induration before treatment with thalidomide.

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References

    1. Rongioletti F., Kaiser F., Cinotti E. Scleredema. A multicentre study of characteristics, comorbidities, course and therapy in 44 patients. J Eur Acad Dermatol Venereol. 2015;29(12):2399–2404. - PubMed
    1. Eastham A.B., Femia A.N., Velez N.F., Smith H.P., Vleugels R.A. Paraproteinemia-associated scleredema treated successfully with intravenous immunoglobulin. JAMA Dermatol. 2014;150(7):788–789. - PubMed
    1. Popadić S., Skiljević D., Antić D., Milenković B., Medenica L. Widespread scleredema associated with paraproteinemia and generalized osteoarthritis in an HLA-B39 positive patient. Acta Dermatovenerol Croat. 2011;19(3):191–194. - PubMed
    1. Ohta A., Uitto J., Oikarinen A.I. Paraproteinemia in patients with scleredema: clinical findings and serum effects on skin fibroblasts in vitro. J Am Acad Dermatol. 1987;16(1 Pt 1):96–107. - PubMed
    1. Kövary P.M., Vakilzadeh F., Macher E., Zaun H., Merk H., Goerz G. Monoclonal gammopathy in scleredema: observations in three cases. Arch Dermatol. 1981;117(9):536–539. - PubMed

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