Accounting for individual variability in baseline seizure frequencies when planning randomized clinical trials remains challenging

Georg Zimmermann^{1

2

3}, Eugen Trinka^{2

4

5}

Affiliations

¹ Team Biostatistics and Big Medical Data, IDA Lab Salzburg, Paracelsus Medical University, Salzburg, Austria.
² Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria.
³ Department of Mathematics, Paris-Lodron-University of Salzburg, Salzburg, Austria.
⁴ Center for Cognitive Neuroscience, Salzburg, Austria.
⁵ Department of Public Health, Health Services Research and Health Technology Assessment, University for Health Sciences, Medical Informatics, and Technology, Hall in Tirol, Austria.

Comment

Georg Zimmermann et al. Epilepsia. 2020 Oct.

. 2020 Oct;61(10):2321-2322.

doi: 10.1111/epi.16676. Epub 2020 Sep 30.

Georg Zimmermann^{1

2

3}, Eugen Trinka^{2

4

5}

¹ Team Biostatistics and Big Medical Data, IDA Lab Salzburg, Paracelsus Medical University, Salzburg, Austria.
² Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria.
³ Department of Mathematics, Paris-Lodron-University of Salzburg, Salzburg, Austria.
⁴ Center for Cognitive Neuroscience, Salzburg, Austria.
⁵ Department of Public Health, Health Services Research and Health Technology Assessment, University for Health Sciences, Medical Informatics, and Technology, Hall in Tirol, Austria.

No abstract available

Comment in

Statistical efficiency of patient data in randomized clinical trials of epilepsy treatments adds value.
Romero J, Goldenholz DM. Romero J, et al. Epilepsia. 2020 Oct;61(10):2323-2324. doi: 10.1111/epi.16677. Epub 2020 Sep 30. Epilepsia. 2020. PMID: 32996130 No abstract available.

Statistical efficiency of patient data in randomized clinical trials of epilepsy treatments.
Romero J, Goldenholz DM. Romero J, et al. Epilepsia. 2020 Aug;61(8):1659-1667. doi: 10.1111/epi.16609. Epub 2020 Jul 13. Epilepsia. 2020. PMID: 32658327