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. 2020 Sep 1;3(9):e2023282.
doi: 10.1001/jamanetworkopen.2020.23282.

Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Infection

Luming Li  1 , Fangyong Li  2 , Frank Fortunati  1 , John H Krystal  1
Affiliations

Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Infection

Luming Li et al. JAMA Netw Open. .

Abstract

This cohort study evaluates the association between prior psychiatric diagnosis and mortality among patients hospitalized with coronavirus disease 2019 (COVID-19).

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Conflict of interest statement

Conflict of Interest Disclosures: Dr L. Li reported grants from a Health and Aging Policy Fellowship during the conduct of the study. Dr Krystal reported receiving royalties from Janssen Pharmaceuticals, stock from Biohaven Pharmaceuticals, stock options from Blackthorn Pharmaceuticals, stock from Spring Health, stock options from Terran Biosciences, personal fees and provision of drugs for research from Novartis, provision of drugs for research from AstraZeneca, personal fees from Sunovion, Takeda, Cerevel, Biogen, EpiVario, Heptares, Otsuka, Taisho, BioXcel, and Psychogenics, stock from Sage, and personal fees from Cadent Pharmaceuticals outside the submitted work and is the editor of Biological Psychiatry and a member of the Society of Biological Psychiatry. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Kaplan-Meier Survival Curves for Hospitalized Patients With Coronavirus Disease 2019, With or Without a Psychiatric Diagnosis
Figure 2.
Figure 2.. Multivariable Cox Hazard Regression Assessing Risk of Death for Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) and Psychiatric Diagnosis
CHF indicates congestive heart failure; COPD, chronic obstructive pulmonary disease; DMC, diabetes with complications; HR, hazard ratio; PI, Pacific Islander. aPsychiatric diagnosis included International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes F01 to 99 (mental and behavioral health), specific codes G30 to 32 (Alzheimer disease), and codes X60 to 63 (self-injury). bThe numbers in each categorical variable correspond with the number of deaths in the numerator and the number of inpatients hospitalized with COVID-19 with that categorical variable in the denominator. cThe HR for age is presented as an increase of risk with every 5-year increase in age. dHospitals A, B, C, and D represent community hospitals affiliated with the health system, and Hospital E represents an academic medical center within the health system. None of the hospitals were rehabilitation hospitals. Although there are psychiatric units associated with the academic medical center and 2 of the community hospitals, the patients who were hospitalized for COVID-19 were hospitalized in the general hospitals for hospital-based care or intensive care.
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