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. 2021 Feb;35(2):e22637.
doi: 10.1002/jbt.22637. Epub 2020 Sep 30.

Association of genetic variants in the 3'-untranslated region of the mesothelin (MSLN) gene with ovarian carcinoma

Amoura M Abou-El-Naga  1 , Salwa M Abo El-Khair  2 , Ashraf Z Mahmoud  3 , Mohamed Hamza  1 , Rami M Elshazli  4
Affiliations

Association of genetic variants in the 3'-untranslated region of the mesothelin (MSLN) gene with ovarian carcinoma

Amoura M Abou-El-Naga et al. J Biochem Mol Toxicol. 2021 Feb.

Abstract

Limited information has been offered regarding the association of mesothelin (MSLN) gene variants at the 3'-untranslated region with the risk of ovarian carcinoma. The primary objective of this work is to assess the impact of the MSLN (rs1057147 and rs57272256) variants on the progression of ovarian carcinoma among Egyptian women. The study was conceived based on 127 women diagnosed with ovarian carcinoma and 106 unrelated cancer-free controls. Genomic DNA of these MSLN variants was genotyped utilizing the PCR technique. The frequencies of the MSLN (rs1057147) variant revealed a significant association with increased risk of ovarian carcinoma under allelic and dominant models (P < .05). Nonetheless, ovarian cancer patients with the MSLN (rs57272256) variant did not attain considerable significance under all genetic models (P > .05). Together, our findings suggested that the MSLN (rs1057147) variant was associated with an increased risk of ovarian carcinoma, but not the MSLN (rs57272256) variant.

Keywords: MSLN; genetic variants and ovarian carcinoma; rs1057147; rs57272256.

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