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. 2020 Oct;11(Suppl 5):S856-S860.
doi: 10.1016/j.jcot.2020.07.027. Epub 2020 Jul 29.

The analysis of alendronate action in bone fracture healing in rats

Francisco de Assis Serra Baima Filho  1 , Priscylla Gouveia Mendonça  1 , Gyl Eanes Barros Silva  1 , Orlando José Dos Santos  1 , João Batista Santos Garcia  1 , Maria do Socorro de Sousa Cartagenes  1
Affiliations

The analysis of alendronate action in bone fracture healing in rats

Francisco de Assis Serra Baima Filho et al. J Clin Orthop Trauma. 2020 Oct.

Erratum in

  • Erratum regarding previously published articles.
    [No authors listed] [No authors listed] J Clin Orthop Trauma. 2021 Aug 5;21:101558. doi: 10.1016/j.jcot.2021.101558. eCollection 2021 Oct. J Clin Orthop Trauma. 2021. PMID: 34414072 Free PMC article.

Abstract

Introduction: Osteoporosis is defined as a systemic skeletal disease characterized by reduced bone mass and degeneration of bone tissue microarchitecture which leads to bone fragility and fracture risk. Annually, 100 to 200 million people around the world are at risk for osteoporotic fractures. One way to prevent osteoporosis fracture is by using medications such as bisphosphonates. Alendronate is the most prescribed bisphosphonate in the world. The objective of this article is to evaluate the effect of alendronate on bone fracture healing.

Material and methods: 15 adult male rats that were 60 days old were used, divided into three groups: A or Control, B (non-osteoporotic bones plus alendronate application) and C (osteoporotic bones plus alendronate application). Osteoporotic bones were compared with non-osteoporotic bones that underwent bone window creation and administration of alendronate sodium. These bones were submitted to radiographic and histological analysis.

Results: All of Group A had complete bone healing, reaching the phase of bone remodeling. While in groups B and C, the rats were in the repair phase.

Conclusions: The drug alendronate interferes with delayed fracture healing and delayed bone remodeling. The article advises that studies in humans are needed in order to assess whether the alendronate interferes with bone healing.

Keywords: Alendronate (MeSH ID: D019386); Bone fracture (MeSH ID: D050723); Corticoid (MeSH ID: 000305); Fracture healing (MeSH ID: D017102); Osteoporosis (MeSH ID: D010024).

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Figures

Fig. 1
Fig. 1
Visualization of bone window in rat tibia.
Fig. 2
Fig. 2
Shows the radiographs taken in D1 with a representative from each group. The arrows point to the locations of the bone defect.
Fig. 3
Fig. 3
Radiographs of the tibiae of rats, with a representative from group A, one from group B and one from group C. Figure A: complete consolidation with little area of reaction sclerosis (∗). Figure B: complete bone consolidation with a large area of reactional sclerosis (∗). Figure C: absence of bone healing (∗).
Fig. 4
Fig. 4
Histological sections in hematoxylin-eosin with a representative of groups A, B and C. Figure A: histological section (10x) of group A with emphasis on bone marrow. Figure B: histological section (10x) of group B highlighting the absence of bone marrow. Figure C: histological section (20x) of group C with evidence of hyaline cartilage bridge.
See this image and copyright information in PMC

References

    1. Pedro Henrique B Mendes, Junior Scofano, Romeu Antônio. Consolidação da fratura após o uso prolongado de corticóide : estudo experimental em ratos ∗. Rev Bras Ortop. 2001;36:345–351.
    1. Oryan A., Monazzah S., Bigham-sadegh A. Bone injury and fracture healing biology. Biomed Environ Sci. 2015;28(1):57–71. - PubMed
    1. Bucholz R.W., Heckman J.D., Court-Brown C.M., Tornetta P., McQueen M.M., Ricci W.M. 7 ed. vol. 1. Manole, organizador; 2013. pp. 54–55. (Fraturas Em Adultos).
    1. Ruedi T.P., Buckley R.E., Moran C.G. 2 ed. ARTMED, organizador; 2009. Princípios AO do tratamento de fraturas; p. 493.
    1. Cezar S., Bernardo W., Patrícia A. Artigo original Diretrizes brasileiras para o diagnóstico e tratamento da osteoporose em mulheres na pós-menopausa. 2017;7(S 2):452–466.