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Case Reports
. 2020 Aug 14;13(2):956-961.
doi: 10.1159/000509074. eCollection 2020 May-Aug.

Male Breast Carcinoma after Irradiation and Long-Term Phenothiazine Exposure: A Case Report

Ragnar Hultborn  1 , Toshima Z Parris  2 , Khalil Helou  2 , Åke Borg  3 , Shahin De Lara  4 , Anikó Kovács  4
Affiliations
Case Reports

Male Breast Carcinoma after Irradiation and Long-Term Phenothiazine Exposure: A Case Report

Ragnar Hultborn et al. Case Rep Oncol. .

Abstract

We present a young male patient with breast cancer having several risk factors likely acting in consort: irradiation of the breast for gynecomastia in adolescence and a life-long administration of phenothiazine for schizophrenia from the age of 16 years, with elevated serum prolactin level resulting in breast cancer development 24 years after irradiation.

Keywords: BRCA1; Hyperprolactinemia; Irradiation; Male breast cancer; Phenothiazine; Schizophrenia.

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Conflict of interest statement

No conflicts of interest from any of the authors.

Figures

Fig. 1
Fig. 1
Timeline showing the consecutive events during the patient's life.
Fig. 2
Fig. 2
Invasive ductal carcinoma. HE. ×200 (top left). Androgen receptor immunostaining, ×200 (top right). Progesterone receptor immunostaining, ×200 (middle left). Ki-67 proliferation marker immunostaining, ×200 (middle right). HercepTest for HER2 immunostaining (score 0), ×200 (bottom left). Local recurrence of invasive ductal carcinoma in musculus pectoralis major, ×40 (autopsy material; bottom right).
See this image and copyright information in PMC

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