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. 2020 Sep 26:8:74.
doi: 10.1186/s40560-020-00493-w. eCollection 2020.

The authors' response

Ofer Sadan  1 , Owen Samuels  1
Affiliations

The authors' response

Ofer Sadan et al. J Intensive Care. .

Abstract

In response to comments raised, we acknowledge the shortcomings of our study. It is a small study. However, it is a pilot study, which is not meant to create generalizable data, rather to explore new potential directions. To this end, our conclusions were clearly supported by the results. We demonstrated that administration of 16.4% NaCl/Na-acetate solution was feasible, safe, and was associated with lower rates of AKI. We share the call that large RCTs are required to follow this pilot study and hope that our data will stimulate the ongoing discussion regarding the role of chloride in AKI mechanism.

Keywords: Acute kidney injury; Cerebral edema; Hyperchloremia; Hyperosmolar therapy; Neurocritical care; Subarachnoid hemorrhage.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 3
Fig. 3
b Histogram of AKI frequency by group of treatment and hospitalization day
See this image and copyright information in PMC

References

    1. Sadan O, Singbartl K, Kraft J, et al. Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage-related complications: the ACETatE (a low ChloriE hyperTonic solution for brain edema) randomized trial. J Intensive Care. 2020;8:32. doi: 10.1186/s40560-020-00449-0. - DOI - PMC - PubMed

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