[Blood insulin and characteristics of nitrogen metabolism in organs during myocardial necrosis developing after emotional stress]

Abstract

Simulation of myocardium necrosis developed after emotional stress led to hyperinsulinemia and hyperglycemia simultaneously with a decrease in arterial-venous difference of oxygen. In control, stress-treated animals, hypoinsulinemia and hyperglycemia were detected. Dissimilar alterations in nitrogen metabolism were observed in heart and brain tissues of the animals with myocardium necrosis under conditions of anomalous insulin secretion and glucose consumption. During the first steps of myocardium necrosis after emotional stress increase in content of nucleic acids, ammonium, urea as well as activation of leucine aminopeptidase were found in heart of the animals. At the same time, a number of compensatory reactions, involved in nitrogen metabolism, were not found in brain of the animals with myocardium necrosis; distinct activation of leucine aminopeptidase was detected in the tissue.