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. 2021 Jul;39(7):2795-2800.
doi: 10.1007/s00345-020-03463-x. Epub 2020 Sep 30.

Increasing kidney grafts for transplantation

Mireia Musquera  1 , Alba Sierra  2 , Fritz Diekmann  3 , Meritxell Perez  4 , Claudia Mercader, Lluis Peri  2 , Nuria Esforzado  3 , David Paredes  5 , Antonio Alcaraz  2
Affiliations

Increasing kidney grafts for transplantation

Mireia Musquera et al. World J Urol. 2021 Jul.

Abstract

Introduction: The current pool of organs available for transplantation does not cover requirements, for this reason non-standard risk donors need to be incorporated into the pool. In this way, donors with small renal tumour are considered for transplantation after bench tumour excision. The aim of our study was to analyse our experience in using these grafts for transplantation.

Materials and methods: Retrospective analysis from our prospective accrued database of donors with incidental renal mass used for kidney transplantation between January 2007 and August 2018.

Results: Twenty kidney transplantations were performed, thirteen cases received the affected kidney (after tumour removal) and seven the contralateral kidney; from six living and eleven deceased donors. Donor and recipient median age was 58 years (range 22-82) and 56.5 years (range 38-74), respectively. Mean tumour diameter was 12.7 mm (SD 9.5). Tumours resulted in two benign lesions and fifteen renal cell carcinoma. Surgical margins were negative. Two cases presented with bleeding after reperfusion was solved without repercussion. One case presented with immediate vein thrombosis. None of them present delayed graft function. After a 69 month follow-up none of the donors or the recipients presented tumour recurrence.

Conclusions: Kidneys with small incidental tumours seem to be a good option for kidney transplantation in selected patients after bench surgery excision with good functional and oncologic results. More studies and longer follow-up are needed to confirm these results.

Keywords: Grafts; Kidney transplant; Non-standard risk donors; Renal tumour.

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References

    1. Wolfe RA, Ashby VB, Milford EL et al (1999) Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 341(23):1725–1730 - DOI
    1. Buell JF, Beebe TM, Trofe J et al (2004) Donor transmitted malignancies. Ann Trasplant 9:53–56
    1. Memoria de Actividad. ONT 2017. https://www.ont.es/infesp/Memorias/Memoria%20Donaci%C3%B3n%202017.pdf
    1. Chow W-H, Devesa SS, Warren JL et al (1999) Rising incidence of renal cell cancer in the United States. JAMA 281(17):1628–1631 - DOI
    1. Hollingsworth JM1, Miller DC, Daignault S, Hollenbeck BK (2006) Rising incidence of small renal masses: a need to reassess treatment effect. J Natl Cancer Inst 98(18):1331–1334 - DOI

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