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Review
. 2021 Mar;35(3):1176-1186.
doi: 10.1002/ptr.6883. Epub 2020 Sep 30.

Roles of plant-derived bioactive compounds and related microRNAs in cancer therapy

Heng Zou  1 , Yanli Li  1 , Xiaomin Liu  1 , Zong Wu  1 , Jingjing Li  2 , Zhongliang Ma  1
Affiliations
Review

Roles of plant-derived bioactive compounds and related microRNAs in cancer therapy

Heng Zou et al. Phytother Res. 2021 Mar.

Abstract

Plant-derived bioactive compounds, often called phytochemicals, are active substances extracted from different plants. These bioactive compounds can release therapeutic potential abilities via reducing antitumor drugs side effects or directly killing cancer cells, and others also can adjust cancer initiation and progression via regulating microRNAs (miRNAs) expression, and miRNA can regulate protein-coding expression by restraining translation or degrading target mRNA. A mass of research showed that plant-derived bioactive compounds including tanshinones, astragaloside IV, berberine, ginsenosides and matrine can inhibit tumor growth and metastasis by rescuing aberrant miRNAs expression, which has influence on tumor progression, microenvironment and drug resistance in multifarious cancers. This review aims to provide a novel understanding of plant-derived bioactive compounds targeting miRNAs and shed light on their future clinical applications.

Keywords: NcRNA; cancer; miRNAs; novel anticancer agents; phytochemicals; tanshinones.

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References

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