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. 2020 Oct 1;15(1):274.
doi: 10.1186/s13023-020-01552-z.

Safety of vaccines administration in hereditary fructose intolerance

Arianna Maiorana  1 , Antonella Sabia  2 , Tiziana Corsetti  2 , Carlo Dionisi-Vici  3
Affiliations

Safety of vaccines administration in hereditary fructose intolerance

Arianna Maiorana et al. Orphanet J Rare Dis. .

Abstract

Patients with hereditary fructose intolerance need to follow a life-long fructose dietary and drug restriction to prevent symptoms of intoxication. Concerns about vaccines administration have been manifested overtime, for the risk of a life-threatening acute intoxication. For this reason, at Ospedale Pediatrico Bambino Gesù we performed a deepen research from open sources, datasheets and Pharmaceutical Companies informations from the most common Italian and European vaccines, which are carried out in infancy and childhood. As a safe threshold of 2.4 mg/kg/dose was recently established for oral and parenteral (other than i.v.) route, the manuscript clarifies the safe administration of majority of vaccines in patients with hereditary fructose intolerance.

Keywords: Fructose; Hereditary fructose intolerance; Sorbitol; Sucrose; Vaccines.

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Conflict of interest statement

The authors declare that they have no competing interests.

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