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. 2021 Feb;75(2):185-188.
doi: 10.1136/jech-2020-214730. Epub 2020 Oct 1.

SARS-CoV-2 infection in London, England: changes to community point prevalence around lockdown time, March-May 2020

Michael Edelstein  1 , Chinelo Obi  2 , Meera Chand  2 , Susan Hopkins  2 , Kevin Brown  2 , Mary Ramsay  2
Affiliations

SARS-CoV-2 infection in London, England: changes to community point prevalence around lockdown time, March-May 2020

Michael Edelstein et al. J Epidemiol Community Health. 2021 Feb.

Abstract

Background: The UK has been one of the European countries most affected by COVID-19 pandemic. The UK implemented a lockdown in March 2020, when testing policy at the time was focusing on hospitalised cases. Limited information is therefore available on the impact of the lockdown on point prevalence in the community. We assessed COVID-19 point prevalence in London between early April and early May 2020, which approximately reflect infection around the time of the lockdown and 3-5 weeks into lockdown.

Methods: We tested 1064 participants of a community surveillance cohort for acute COVID-19 infection using PCR in London in April and May 2020 and described positivity as well as characteristics and symptoms of the participants.

Results: Point prevalence decreased from 2.2% (95% CI 1.4 to 3.5) in early April to 0.2% (95% CI 0.03 to 1.6) in early May. 22% of those who tested positive in April were asymptomatic. Extrapolation from reports of confirmed cases suggest that 5-7.6% of total infections were confirmed by testing during this period.

Conclusion: COVID-19 point prevalence in the community sharply decreased after lockdown was implemented. This study is based on a small sample and regular seroprevalence studies are needed to better characterise population-level immunity.

Keywords: Epidemics; communicable diseases; control of diseases.

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Conflict of interest statement

Competing interests: This study was conducted by Public Health England as part of routine surveillance activities.

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