Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan;17(1):33-45.
doi: 10.1038/s41581-020-00338-7. Epub 2020 Oct 1.

Challenges of access to kidney care for children in low-resource settings

Affiliations
Review

Challenges of access to kidney care for children in low-resource settings

Mignon McCulloch et al. Nat Rev Nephrol. 2021 Jan.

Abstract

Kidney disease is a global public health concern across the age spectrum, including in children. However, our understanding of the true burden of kidney disease in low-resource areas is often hampered by a lack of disease awareness and access to diagnosis. Chronic kidney disease (CKD) in low-resource settings poses multiple challenges, including late diagnosis, the need for ongoing access to care and the frequent unavailability of costly therapies such as dialysis and transplantation. Moreover, children in such settings are at particular risk of acute kidney injury (AKI) owing to preventable and/or reversible causes - many children likely die from potentially reversible kidney disease because they lack access to appropriate care. Acute peritoneal dialysis (PD) is an important low-cost treatment option. Initiatives, such as the Saving Young Lives programme, to train local medical staff from low-resource areas to provide care for AKI, including acute PD, have already saved hundreds of children. Future priorities include capacity building for both educational purposes and to provide further resources for AKI management. As local knowledge and confidence increase, CKD management strategies should also develop. Increased awareness and advocacy at both the local government and international levels will be required to continue to improve the diagnosis and treatment of AKI and CKD in children worldwide.

PubMed Disclaimer

References

    1. Jager, K. J. et al. A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases. Kidney Int. 96, 1048–1050 (2019). - PubMed
    1. Mehta, R. L. et al. International Society of Nephrology’s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet 385, 2616–2643 (2015). This article summarized the global challenge of AKI and advocates for increased awareness, prompt treatment and more equity in access to care. - PubMed
    1. Macedo, E., Garcia-Garcia, G., Mehta, R. L. & Rocco, M. V. International Society of Nephrology 0 by 25 project: lessons learned. Ann. Nutr. Metab. 74 (Suppl 3), 45–50 (2019). - PubMed
    1. Hill, N. R. et al. Global prevalence of chronic kidney disease — a systematic review and meta-analysis. PLoS One 11, e0158765 (2016). - PubMed - PMC
    1. Liyanage, T. et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet 385, 1975–1982 (2015). - PubMed

MeSH terms

Substances

Supplementary concepts

LinkOut - more resources