Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Sep 29:9:27.
doi: 10.1186/s40164-020-00181-3. eCollection 2020.

The global, regional, and national burden of kidney cancer and attributable risk factor analysis from 1990 to 2017

Xianguang Bai #  1   2 , Ming Yi #  2 , Bing Dong  3 , Xinhua Zheng  1 , Kongming Wu  2   3
Affiliations

The global, regional, and national burden of kidney cancer and attributable risk factor analysis from 1990 to 2017

Xianguang Bai et al. Exp Hematol Oncol. .

Abstract

Background: Kidney cancer's incidence and mortality vary in different regions and countries. To compare and interpret kidney cancer's burden and change trends in the globe and in different countries, we conducted this study to report the global kidney cancer burden and attributable risk factors.

Methods: Data about kidney cancer's incidence, death, disability-adjusted life-year (DALY) were extracted from the Global Burden of Diseases 2017. Besides, social-demographic index (SDI) values were adopted to investigate the correlation between kidney cancer's burden and social development degrees.

Results: In the globe, the incidence case of kidney cancer increased sharply from 207.31*103 in 1990 to 393.04*103 in 2017. High SDI countries had the highest kidney cancer's burden with a decreased trend in incidence rate. On the contrary, the incidence rate was rapidly increased in low-middle SDI countries, although their burden of kidney cancer kept relatively low. At the same time, the deaths of kidney cancer increased from 68.14*103 to 138.53*103, and the kidney cancer-related DALYs increased from 1915.49*103 in 1990 to 3284.32*103 in 2017. Then, we searched the GBD database for kidney cancer-related risk factor. The high body-mass index and smoking were the main factors contributing to kidney cancer-related mortality.

Conclusions: Generally, from 1990 to 2017, the incidence rate in developed countries had gone down from the historic peak values while the incidence rate was still on the rise in developing counties. Given the aging trend in the globe, it is necessary to appeal to the public to decrease the exposure of kidney cancer-associated risk factors.

Keywords: Attributable risk factor; Cancer epidemiology; Global burden of diseases; Kidney cancer; Social-demographic index.

PubMed Disclaimer

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The change trends of kidney cancer’s incidence cases, deaths, and DALYs from 1990 to 2017. a The change trends of incidences; b the change trends of deaths; c the change trends of DALYs. Note: DALY, disability-adjusted life year
Fig. 2
Fig. 2
The change trends of kidney cancer’s ASIR, ASDR, and age-standardized DALY rate from 1990 to 2017. a The change trends of ASIR; b the change trends of ASDR; c the change trends of age-standardized DALY rate. Note: ASIR, Age-standardized incidence rate; ASDR, Age-standardized death rate; DALY, disability-adjusted life year
Fig. 3
Fig. 3
The global disease burden of kidney cancer in 195 countries or territories. a The incidence cases of 195 countries in 2017; b the deaths of 195 countries in 2017; c the DALYs of 195 countries in 2017. Note: DALY, disability-adjusted life year
Fig. 4
Fig. 4
The age-standardized rates of kidney cancer in 195 countries or territories. a The ASIR of 195 countries in 2017; b the ASDR of 195 countries in 2017; c the age-standardized DALY rate of 195 countries in 2017. Note: ASIR, Age-standardized incidence rate; ASDR, Age-standardized death rate; DALY, disability-adjusted life year
Fig. 5
Fig. 5
The correlation analyses of ASRs and SDI values from 1990 to 2017. a The correlation of ASIR and SDI from 1990 to 2017. b The correlation of ASDR and SDI from 1990 to 2017. c The correlation of age-standardized DALY rate and SDI from 1990 to 2017. Note: ASIR, Age-standardized incidence rate; ASDR, Age-standardized death rate; DALY, disability-adjusted life year; SDI, Socio-demographic Index
Fig. 6
Fig. 6
The change trends of incidence and ASIR of kidney cancer in different age groups. a The incidence cases of kidney cancer in five different age groups in the globe and in various regions. The ASIR of kidney cancer in five different age groups in the world and in various regions. Note: ASIR, Age-standardized incidence rate; SDI, Socio-demographic Index
Fig. 7
Fig. 7
Risk factors contributing to kidney cancer-related death and DALY. a Three risk factors contributing to kidney cancer-related death from 1990 to 2017 in the globe and different regions; b three risk factors contributing to AML-related DALY from 1990 to 2017 in the world and different regions; Note: DALY, disability-adjusted life year; SDI, Socio-demographic Index
See this image and copyright information in PMC

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34. - PubMed
    1. Levi F, Ferlay J, Galeone C, Lucchini F, Negri E, Boyle P, et al. The changing pattern of kidney cancer incidence and mortality in Europe. BJU Int. 2008;101:949–958. doi: 10.1111/j.1464-410X.2008.07451.x. - DOI - PubMed
    1. Capitanio U, Montorsi F. Renal cancer. Lancet. 2016;387:894–906. doi: 10.1016/S0140-6736(15)00046-X. - DOI - PubMed
    1. Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 2010;7:245–257. doi: 10.1038/nrurol.2010.46. - DOI - PMC - PubMed
    1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29. doi: 10.3322/caac.21208. - DOI - PubMed