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. 2021 Aug;199(8):2811-2818.
doi: 10.1007/s12011-020-02410-6. Epub 2020 Oct 1.

Estimation of Selected Minerals in Aortic Aneurysms-Impaired Ratio of Zinc to Lead May Predispose?

Katarzyna Socha  1 , Alicja Karwowska  2 , Adam Kurianiuk  2 , Renata Markiewicz-Żukowska  3 , Andrzej Guzowski  4 , Marek Gacko  4 , Tomasz Hirnle  5 , Maria H Borawska  3
Affiliations

Estimation of Selected Minerals in Aortic Aneurysms-Impaired Ratio of Zinc to Lead May Predispose?

Katarzyna Socha et al. Biol Trace Elem Res. 2021 Aug.

Abstract

The objective of this study was to estimate the content of copper, zinc, selenium, cadmium, and lead in the tissue of patients with aortic aneurysms. Molar ratio of Cu/Zn and antioxidant micronutrients to toxic elements was also calculated. A total of 108 patients: 47 with abdominal aortic aneurysm (AAA), 61 patients with thoracic aortic aneurysm (TAA), and a control group of 20 abdominal aortic (AA) and 20 thoracic aortic (TA) wall samples from the deceased were studied. The concentrations of mineral components in the tissue samples were determined by the AAS method. The average concentration of Cu in the aortic wall of patients with TAA was significantly lower than in the aortic wall samples of healthy people. The mean concentration of Zn in the aortic wall of patients with AAA and TAA was significantly lower than in the control group samples. Cu/Zn ratio was significantly higher in AAA patients than in control group which indicates a greater role of oxidative stress and inflammatory process in this type of aneurysm. The concentration of Se was significantly decreased in TAA patients compared with the control group; in turn, the concentration of Pb was increased in this group of patients. We observed significantly lower Cu/Pb ratio in TAA patients than in control group, whereas Zn/Pb ratio was significantly lower comparing with control samples in both types of aneurysms. In the examined aneurysms, we have shown the differences in concentrations of mineral components compared with the control tissues. The Zn concentration was decreased in both AAA and TAA samples. Impaired ratio of Zn to Pb may predispose to aortic aneurysms.

Keywords: Aortic aneurysm; Cadmium; Copper; Lead; Selenium; Zinc.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Molar ratio between antioxidant components and toxic elements in tissue samples of aortic aneurysms and in the control samples. Median values with lower and upper quartiles, AA–abdominal aorta, AAA–abdominal aortic aneurysm, TA–thoracic aorta, TAA–thoracic aortic aneurysm, *p < 0.05
See this image and copyright information in PMC

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