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Review
. 2020 Dec;68(6):315-324.
doi: 10.1007/s12026-020-09154-4. Epub 2020 Oct 1.

Recent advances, approaches and challenges in targeting pathways for potential COVID-19 vaccines development

Daniela Calina  1 , Chandan Sarkar  2 , Andreea Letitia Arsene  3 , Bahare Salehi  4   5 , Anca Oana Docea  6 , Milon Mondal  2 , Muhammad Torequl Islam  2 , Alireza Zali  7 , Javad Sharifi-Rad  8
Affiliations
Review

Recent advances, approaches and challenges in targeting pathways for potential COVID-19 vaccines development

Daniela Calina et al. Immunol Res. 2020 Dec.

Abstract

During the COVID-19 pandemic in a modern era, there is a global consensus on the need for the rapid development of a vaccine against SARS-CoV-2 for effective and sustainable control. Developing these vaccines is fundamental to public health. This urgent need is supported by the scientific explosion in structural and genomic biology that facilitates the urgent development of an ideal COVID-19 vaccine, using new pathways to facilitate its large-scale development, testing, and manufacture. Here, we summarize the types of COVID-19 candidate vaccines, their current stage in early testing in human clinical trials, and the challenges for their implementation.

Keywords: COVID-19 pandemic; Candidate vaccines; Efficacy; Immunology; Public health; Quality; SARS-CoV-2; Safety.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic mechanism of the neutralizing antibodies. Spike (S) protein binds to the host receptor (ACE2 receptor) and enter into the target cell through membrane fusion. The antibody targeting S protein can effectively block binding, membrane fusion, and entry of SARS-CoV-2 to the ACE2 receptor
Fig. 2
Fig. 2
Vaccines platforms and current status of potential candidate COVID-19 vaccines
Fig. 3
Fig. 3
A comparative scheme regarding the development of normal vaccines versus potential COVID-19 vaccines
See this image and copyright information in PMC

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