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Comment
. 2020 Oct 1;27(4):499-500.
doi: 10.1016/j.stem.2020.09.009.

Defining the First Part of the Oncogenic KRAS Journey

Jihan K Osborne  1 , John D Minna  2
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Free article
Comment

Defining the First Part of the Oncogenic KRAS Journey

Jihan K Osborne et al. Cell Stem Cell. .
Free article

Abstract

Discovered as a proto-oncogene 40 years ago, mutations in KRAS exist in ∼30% of all human cancers. In this issue of Cell Stem Cell,Dost et al. (2020) combine the power of analyzing organoid cultures, patient samples, and mouse models with scRNA-seq to elucidate early events occurring with oncogenic KRAS activation.

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  • Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells.
    Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, Villacorta-Martin C, Huang J, Hekman R, Kwan JH, Blum BC, Louie SM, Rowbotham SP, Sainz de Aja J, Piper ME, Bhetariya PJ, Bronson RT, Emili A, Mostoslavsky G, Fishbein GA, Wallace WD, Krysan K, Dubinett SM, Yanagawa J, Kotton DN, Kim CF. Dost AFM, et al. Cell Stem Cell. 2020 Oct 1;27(4):663-678.e8. doi: 10.1016/j.stem.2020.07.022. Epub 2020 Sep 4. Cell Stem Cell. 2020. PMID: 32891189 Free PMC article.

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