Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Oct 1;27(4):505-507.
doi: 10.1016/j.stem.2020.09.008.

Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes

Jeffrey A Bluestone  1 , Qizhi Tang  2
Affiliations
Free article
Comment

Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes

Jeffrey A Bluestone et al. Cell Stem Cell. .
Free article

Abstract

Type 1 diabetes mellitus results from autoimmune destruction of pancreatic β cells. Insulin treatment is often inadequate in preventing devastating complications. Replacing β cells using stem cell-derived islets while fostering immune tolerance, exemplified in Yoshihara et al., holds the promise of a curative therapy for this disease.

PubMed Disclaimer

Conflict of interest statement

Declaration of Interests J.A.B. is the A.W. and Mary Margaret Clausen Distinguished Professor in Metabolism and Endocrinology and a member of the Scientific Advisory Boards of Arcus Biosciences, Celsius Therapeutics, and VIR Biotechnology. J.A.B. is a member of the Board of Directors of Rheos Medicines and Provention Bio, a company actively involved in the development of Teplizumab and other T1D-directed therapies. J.A.B. is a co-founder, President, and CEO and Q.T. is a co-founder and advisor of Sonoma Biotherapeutics, a company involved in developing novel Treg-based cell therapies for the treatment of autoimmune diseases. J.A.B. and Q.T. hold stock and are compensated by Sonoma Biotherapeutics. J.A.B. holds stock and is compensated by Provention Bio, Arcus Biosciences, Celsius Therapeutics, Rheos Medicines, and VIR Biotechnology. Q.T. is an advisor of Encellin, eGenesis, and Qihan Bio.

Comment on

  • Immune-evasive human islet-like organoids ameliorate diabetes.
    Yoshihara E, O'Connor C, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins AR, Downes M, Evans RM. Yoshihara E, et al. Nature. 2020 Oct;586(7830):606-611. doi: 10.1038/s41586-020-2631-z. Epub 2020 Aug 19. Nature. 2020. PMID: 32814902 Free PMC article.

LinkOut - more resources