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Review
. 2020 Oct 1;27(4):523-531.
doi: 10.1016/j.stem.2020.09.014.

Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges

Shinya Yamanaka  1
Affiliations
Free article
Review

Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges

Shinya Yamanaka. Cell Stem Cell. .
Free article

Abstract

Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable diseases and injuries. Both ESCs and iPSCs are already being used in clinical trials. However, we continue to encounter practical issues that limit their use, including their inherent properties of tumorigenicity, immunogenicity, and heterogeneity. Here, I review two decades of research aimed at overcoming these three difficulties.

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Conflict of interest statement

Declaration of Interests S.Y. is an inventor of patents about iPSC technology. S.Y. is a scientific advisor, without salary, to iPS Academia Japan Inc., which handles licenses of the patents.

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