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Comment
. 2020 Oct 1;80(1):6-8.
doi: 10.1016/j.molcel.2020.09.010.

Hold on Tight: Lagging-Strand DNA Polymerases Synthesize Multiple Okazaki Fragments without Letting Go

Vanessa Kellner  1 , Duncan J Smith  2
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Hold on Tight: Lagging-Strand DNA Polymerases Synthesize Multiple Okazaki Fragments without Letting Go

Vanessa Kellner et al. Mol Cell. .
Free article

Abstract

Kapadia et al. (2020) use an innovative single-molecule imaging approach in yeast cells to measure chromatin association of individual replisome subunits, thereby challenging the notion that lagging-strand DNA polymerases frequently dissociate from replisomes during DNA replication in vivo.

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