Androgen deprivation therapy in unlikely to be effective for treatment of COVID-19

M E O'Callaghan¹, A Jay², G Kichenadasse³, K L Moretti⁴

Affiliations

¹ Urology Unit, Flinders Medical Centre, Bedford Park, Australia; College of Medicine and Public Health, Flinders University, Bedford Park, Australia; The Freemasons Centre for Male Health and Wellbeing, Adelaide University, Adelaide. Electronic address: michael.ocallaghan@health.sa.gov.au.
² Urology Unit, Flinders Medical Centre, Bedford Park, Australia; College of Medicine and Public Health, Flinders University, Bedford Park, Australia.
³ College of Medicine and Public Health, Flinders University, Bedford Park, Australia; Medical Oncology Unit, Flinders Medical Centre, Bedford Park, Australia.
⁴ College of Medicine and Public Health, Flinders University, Bedford Park, Australia; The Freemasons Centre for Male Health and Wellbeing, Adelaide University, Adelaide; Urology Unit, The Queen Elizabeth Hospital, Woodville, Australia; The UniSA Allied Health & Human Performance, The University of South Australia, Adelaide; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

PMID: 33007381
PMCID: PMC7525325
DOI: 10.1016/j.annonc.2020.09.014

Comment

Androgen deprivation therapy in unlikely to be effective for treatment of COVID-19

M E O'Callaghan et al. Ann Oncol. 2020 Dec.

. 2020 Dec;31(12):1780-1782.

doi: 10.1016/j.annonc.2020.09.014. Epub 2020 Sep 30.

Authors

M E O'Callaghan¹, A Jay², G Kichenadasse³, K L Moretti⁴

Affiliations

¹ Urology Unit, Flinders Medical Centre, Bedford Park, Australia; College of Medicine and Public Health, Flinders University, Bedford Park, Australia; The Freemasons Centre for Male Health and Wellbeing, Adelaide University, Adelaide. Electronic address: michael.ocallaghan@health.sa.gov.au.
² Urology Unit, Flinders Medical Centre, Bedford Park, Australia; College of Medicine and Public Health, Flinders University, Bedford Park, Australia.
³ College of Medicine and Public Health, Flinders University, Bedford Park, Australia; Medical Oncology Unit, Flinders Medical Centre, Bedford Park, Australia.
⁴ College of Medicine and Public Health, Flinders University, Bedford Park, Australia; The Freemasons Centre for Male Health and Wellbeing, Adelaide University, Adelaide; Urology Unit, The Queen Elizabeth Hospital, Woodville, Australia; The UniSA Allied Health & Human Performance, The University of South Australia, Adelaide; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.

PMID: 33007381
PMCID: PMC7525325
DOI: 10.1016/j.annonc.2020.09.014

No abstract available

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Conflict of interest statement

Disclosure The authors have declared no conflicts of interest.

Figures

**Figure 1**
ADT treatment for COVID 19 in context. ADT, androgen deprivation therapy; COVID-19, coronavirus disease 2019.

See this image and copyright information in PMC

Comment on

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532).
Montopoli M, Zumerle S, Vettor R, Rugge M, Zorzi M, Catapano CV, Carbone GM, Cavalli A, Pagano F, Ragazzi E, Prayer-Galetti T, Alimonti A. Montopoli M, et al. Ann Oncol. 2020 Aug;31(8):1040-1045. doi: 10.1016/j.annonc.2020.04.479. Epub 2020 May 6. Ann Oncol. 2020. PMID: 32387456 Free PMC article.

References

1. Montopoli M., Zumerle S., Vettor R. Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532) Ann Oncol. 2020;31:1040–1045. 1040-1045. - PMC - PubMed
1. Bagrodia A., Diblasio C.J., Wake R.W., Derweesh I.H. Adverse effects of androgen deprivation therapy in prostate cancer: current management issues. Indian J Urol. 2009;25:169–176. 169-176. - PMC - PubMed
1. O'Farrell S., Garmo H., Holmberg L., Adolfsson J., Stattin P., Van Hemelrijck M. Risk and timing of cardiovascular disease after androgen-deprivation therapy in men with prostate cancer. J Clin Oncol. 2015;33:1243–1251. 1243-1251. - PubMed

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Androgen deprivation therapy in unlikely to be effective for treatment of COVID-19

Affiliations

Androgen deprivation therapy in unlikely to be effective for treatment of COVID-19

Authors

Affiliations

Conflict of interest statement

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