Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan:163:105224.
doi: 10.1016/j.phrs.2020.105224. Epub 2020 Sep 29.

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Yu-Qiong He  1 , Can-Can Zhou  2 , Lu-Yao Yu  1 , Liang Wang  1 , Jiu-Ling Deng  1 , Yu-Long Tao  3 , Feng Zhang  4 , Wan-Sheng Chen  5
Affiliations
Review

Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

Yu-Qiong He et al. Pharmacol Res. 2021 Jan.

Abstract

Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) as common life-threatening lung diseases with high mortality rates are mostly associated with acute and severe inflammation in lungs. With increasing in-depth studies of ALI/ARDS, significant breakthroughs have been made, however, there are still no effective pharmacological therapies for treatment of ALI/ARDS. Especially, the novel coronavirus pneumonia (COVID-19) is ravaging the globe, and causes severe respiratory distress syndrome. Therefore, developing new drugs for therapy of ALI/ARDS is in great demand, which might also be helpful for treatment of COVID-19. Natural compounds have always inspired drug development, and numerous natural products have shown potential therapeutic effects on ALI/ARDS. Therefore, this review focuses on the potential therapeutic effects of natural compounds on ALI and the underlying mechanisms. Overall, the review discusses 159 compounds and summarizes more than 400 references to present the protective effects of natural compounds against ALI and the underlying mechanism.

Keywords: Acute lung injury; Acute respiratory distress syndrome; Baicalin (PubChem CID: 64982); Chemical structures; Curcumin (PubChem CID: 969516); Emodin (PubChem CID: 3220); Hydroxysafflor yellow A (PubChem CID: 6443665); Kaempferol (PubChem CID: 5280863); Luteolin (PubChem CID: 5280445); Mechanisms; Natural compounds; Osthole (PubChem CID: 10228); Quercetin (PubChem CID: 5280343); Resveratrol (PubChem CID: 445154); Tanshinone IIA (PubChem CID: 164676).

PubMed Disclaimer

Conflict of interest statement

The authors report no declarations of interest.

Figures

None
Graphical abstract
Fig. 1
Fig. 1
The molecular mechanisms of ALI. The black arrow refers to the role of promotion, the symbol “formula image” refers to the role of inhibition, the symbol “formula image” refers to down-regulation, and the symbol “formula image” refers to up-regulation.
Fig. 2
Fig. 2
The mechanisms underlying the inhibitory effects of natural flavonoid compounds on ALI. The number represents the corresponding compound. The arrow refers to the role of promotion, the symbol “formula image” refers to the role of inhibition.
Fig. 3
Fig. 3
The mechanisms underlying the inhibitory effects of natural alkaloid compounds on ALI. The number represents the corresponding compound. The arrow refers to the role of promotion, the symbol “formula image” refers to the role of inhibition.
Fig. 4
Fig. 4
The mechanisms underlying the inhibitory effects of natural terpenoid compounds on ALI. The number represents the corresponding compound. The arrow refers to the role of promotion, the symbol “formula image” refers to the role of inhibition.
Fig. 5
Fig. 5
The mechanisms underlying the inhibitory effects of natural polyphenol compounds on ALI. The number represents the corresponding compound. The arrow refers to the role of promotion, the symbol “formula image” refers to the role of inhibition.
Fig. 6
Fig. 6
The mechanisms underlying the inhibitory effects of natural quinonoid compounds on ALI. The number represents the corresponding compound. The arrow refers to the role of promotion, the symbol “formula image” refers to the role of inhibition.
Fig. 7
Fig. 7
The mechanisms underlying the inhibitory effects of other compounds on ALI. The number represents the corresponding compound. The arrow refers to the role of promotion, the symbol “formula image” refers to the role of inhibition.
See this image and copyright information in PMC

References

    1. Shaw T.D., McAuley D.F., O’Kane C.M. Emerging drugs for treating the acute respiratory distress syndrome. Expert Opin. Emerg. Drugs. 2019;24(1):29–41. - PubMed
    1. Suresh R., Kupfer Y., Tessler S. Acute respiratory distress syndrome. N. Engl. J. Med. 2000;343(9):660–661. - PubMed
    1. Lu Y., Song Z., Zhou X., Huang S., Zhu D., Yang C.B.X., Sun B., Spragg R., Shanghai A.S.G. A 12-month clinical survey of incidence and outcome of acute respiratory distress syndrome in Shanghai intensive care units. Intensive Care Med. 2004;30(12):2197–2203. - PubMed
    1. Killien E.Y., Mills B., Watson R.S., Vavilala M.S., Rivara F.P. Morbidity and mortality among critically injured children with acute respiratory distress syndrome. Crit. Care Med. 2019;47(2):e112–e119. - PMC - PubMed
    1. Prasertsan P., Anuntaseree W., Ruangnapa K., Saelim K., Geater A. Severity and mortality predictors of pediatric acute respiratory distress syndrome according to the pediatric acute lung injury consensus conference definition. Pediatr. Crit. Care Med. 2019;20(10):e464–e472. - PubMed

Publication types

MeSH terms