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Editorial
. 2020 Nov 12;56(5):2003147.
doi: 10.1183/13993003.03147-2020. Print 2020 Nov.

Inflammation and intussusceptive angiogenesis in COVID-19: everything in and out of flow

Maximilian Ackermann  1   2 , Steven J Mentzer  3 , Martin Kolb  4 , Danny Jonigk  5   6
Affiliations
Editorial

Inflammation and intussusceptive angiogenesis in COVID-19: everything in and out of flow

Maximilian Ackermann et al. Eur Respir J. .

Abstract

Inflammation and intussusceptive angiogenesis in COVID-19 https://bit.ly/30lLh8K

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Conflict of interest statement

Conflict of interest: M. Ackermann has nothing to disclose. Conflict of interest: S.J. Mentzer has nothing to disclose. Conflict of interest: M. Kolb reports grants and personal fees from Roche, Boehringer Ingelheim and Prometic, grants from GSK, Respivert, Alkermes, Pharmaxis and Canadian Institute for Health Research, personal fees from Genoa, Indalo, Third Pole and Pieris, outside the submitted work. Conflict of interest: D. Jonigk has nothing to disclose.

Figures

FIGURE 1
FIGURE 1
a) Schematic of pulmonary endothelialitis, thrombosis, and intussusceptive angiogenesis in coronavirus disease 2019 (COVID-19). SARS-CoV-2: severe acute respiratory syndrome coronavirus 2. b) Intussusceptive angiogenesis is a morphogenetic process which rapidly expands the vascular plexus. c) Transmission electron micrograph of lung tissue of a deceased COVID-19 patient highlights the formation of an intussusceptive pillar (red arrowheads) which spans the lumen of the vascular walls. rbc: red blood cells. d) A disrupted vascularity with distorted vessels and intussusceptive pillars (blue arrowheads) is observed in COVID-19 lungs, as depicted as scanning electron micrograph of microvascular corrosion casts of COVID-19 autopsies.
See this image and copyright information in PMC

References

    1. Ackermann M, Verleden SE, Kuehnel M, et al. . Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med 2020; 383: 120–128. doi:10.1056/NEJMoa2015432. - DOI - PMC - PubMed
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    1. Huertas A, Montani D, Savale L, et al. . Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)? Eur Respir J 2020; 56: 2001634. doi:10.1183/13993003.01634-2020 - DOI - PMC - PubMed
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    1. Ackermann M, Mentzer SJ, Jonigk D. Pulmonary vascular pathology in Covid-19. Reply. N Engl J Med 2020; 383: 888–889. doi:10.1056/NEJMc2022068. - DOI - PubMed

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