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Review
. 2021 May;28(5):390-399.
doi: 10.1038/s41417-020-00234-z. Epub 2020 Oct 2.

The changing face of gastric cancer: epidemiologic trends and advances in novel therapies

Raghav Chandra  1 , Neeraja Balachandar  2 , Sam Wang  1 , Scott Reznik  3 , Herbert Zeh  1 , Matthew Porembka  4
Affiliations
Review

The changing face of gastric cancer: epidemiologic trends and advances in novel therapies

Raghav Chandra et al. Cancer Gene Ther. 2021 May.

Abstract

Gastric cancer is an aggressive solid-tumor malignancy with poor prognosis. The epidemiologic face of gastric cancer is changing and further insight into its heterogenous immunohistopathologic nature is needed to develop personalized therapies for specific patient populations. In this review, we highlight changes in gastric cancer epidemiology with a special emphasis on racial and ethnic variations and discuss the implications of current clinical and preclinical treatment advances.

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References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. - DOI
    1. Correa P. Gastric cancer: two epidemics? Dig Dis Sci. 2011;56:1585–6. - PubMed - DOI
    1. Wang SC, Yeu Y, Hammer STG, Xiao S, Zhu M, Hong C, et al. Hispanic/Latino patients with gastric adenocarcinoma have distinct molecular profiles including a high rate of germline CDH1 variants. Cancer Res. 2020;80:2114–24. - PubMed - PMC - DOI
    1. North American Association of Central Cancer Registries. NAACCR Fast Stats: an interactive tool for quick access to key NAACCR cancer statistics. 2019. https://faststats.naaccr.org/selections.php?#Output .
    1. Surveillance E, End Results Program. Cancer Stat Facts: Stomach Cancer. 2019. https://seer.cancer.gov/statfacts/html/stomach.html .

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