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Case Reports
. 2021 Feb;24(1):48-52.
doi: 10.1007/s11102-020-01085-5. Epub 2020 Oct 3.

AIP variant causing familial prolactinoma

David M Carty  1 , Rachael Harte  2 , Russell S Drummond  2 , Rebecca Ward  3 , Kesson Magid  4 , David Collier  4 , Martina Owens  5 , Márta Korbonits  4
Affiliations
Case Reports

AIP variant causing familial prolactinoma

David M Carty et al. Pituitary. 2021 Feb.

Abstract

Pathogenic variants in the aryl hydrocarbon receptor-interacting protein (AIP) gene are increasingly recognised as a cause of familial isolated pituitary adenoma. AIP-associated tumours are most commonly growth hormone (GH) producing. In our cohort of 175 AIP mutation positive patients representing 93 kindreds, 139 (79%) have GH excess, 19 have prolactinoma (17 familial and 2 sporadic cases) and out of the 17 clinically non-functioning tumours 4 were subsequently operated and found to be GH or GH & prolactin immunopositive adenoma. Here we report a family with an AIP variant, in which multiple family members are affected by prolactinoma, but none with GH excess. To our knowledge this is the first reported family with an AIP pathogenic variant to be affected solely by prolactinoma. These data suggest that prolactinoma families represent a small subset of AIP mutation positive kindreds, and similar to young-onset sporadic prolactinomas, AIP screening would be indicated.

Keywords: AIP mutation; Familial; Pituitary; Prolactinoma.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Coronal (left) and sagittal (right) MRI images pre treatment
Fig. 2
Fig. 2
Coronal (left) and sagittal (right) MRI images following treatment
Fig. 3
Fig. 3
Pedigree. Filled symbols represent family members with a prolactinoma. Proband (case 1) is indicated by the arrow. Square symbols: male, circles: female
See this image and copyright information in PMC

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