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Review
. 2022 Apr;42(3):557-564.
doi: 10.1007/s10571-020-00975-3. Epub 2020 Oct 3.

Glioma Pericytes Promote Angiogenesis by Producing Periostin

Sara Santos Bernardes  1 , Mauro Cunha Xavier Pinto  2 , Jaime Henrique Amorim  3 , Vasco Ariston de Carvalho Azevedo  4 , Rodrigo Ribeiro Resende  5 , Akiva Mintz  6 , Alexander Birbrair  7   8
Affiliations
Review

Glioma Pericytes Promote Angiogenesis by Producing Periostin

Sara Santos Bernardes et al. Cell Mol Neurobiol. 2022 Apr.

Abstract

Glioma is the prevalent aggressive primary brain tumor, with a very poor prognosis. The absence of advanced understanding of the roles played by the cells within the glioma microenvironment limits the development of effective drugs. A recent study indicates that periostin expressed by pericytes is crucial for glioma angiogenesis. Here, we describe succinctly the results and implications of this discovery in what we know about pericytes within the glioma microenvironment. The emerging knowledge from this work will benefit the development of therapies for gliomas.

Keywords: Glioma; Pericytes; Periostin; Tumor microenvironment.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic illustrating possible roles of periostin derived from pericytes in the glioma microenvironment. Pericytes are attached to the brain vasculature. The study of Huizer and colleagues now indicates that periostin expressed by pericytes can induce angiogenesis within the brain tumor (Huizer et al. 2020). Other studies show the importance of periostin for cancer cells proliferation and migration to secondary sites. State-of-art modern technologies will reveal in detail whether periostin derived from pericytes is essential for these processes within the glioma microenvironment
See this image and copyright information in PMC

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