Application of the LymphGen classification tool to 928 clinically and genetically-characterised cases of diffuse large B cell lymphoma (DLBCL)

Hendrik F P Runge^{1

2}, Stuart Lacy³, Sharon Barrans⁴, Philip A Beer⁵, Daniel Painter³, Alexandra Smith³, Eve Roman³, Cathy Burton⁴, Simon Crouch³, Reuben Tooze^{4

6}, Daniel J Hodson^{1

2}

Affiliations

¹ Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge, UK.
² Department of Haematology, University of Cambridge, Cambridge, UK.
³ Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.
⁴ Haematological Malignancy Diagnostic Service, St. James's Institute of Oncology, Leeds, UK.
⁵ Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
⁶ Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.

Hendrik F P Runge et al. Br J Haematol. 2021 Jan.

. 2021 Jan;192(1):216-220.

doi: 10.1111/bjh.17132. Epub 2020 Oct 3.

¹ Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge, UK.
² Department of Haematology, University of Cambridge, Cambridge, UK.
³ Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.
⁴ Haematological Malignancy Diagnostic Service, St. James's Institute of Oncology, Leeds, UK.
⁵ Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
⁶ Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK.

No abstract available

References

1. Lacy SE, Barrans SL, Beer PA, Painter D, Smith AG, Roman E, et al. Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report. Blood. 2020;135(20):1759-71.
1. Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, et al. Genetics and pathogenesis of diffuse large B-cell lymphoma. N Engl J Med. 2018;378(15):1396-407.
1. Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018;24(5):679-90.
1. Wright GW, Huang DW, Phelan JD, Coulibaly ZA, Roulland S, Young RM, et al. A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications. Cancer Cell. 2020;37(4):551-68.e14.
1. Ennishi D, Jiang A, Boyle M, Collinge B, Grande BM, Ben-Neriah S, et al. Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma. J Clin Oncol. 2019;37(3):190-201.