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Editorial
. 2020 Dec;159(6):2025-2027.
doi: 10.1053/j.gastro.2020.09.037. Epub 2020 Oct 1.

Could a Small Population of Epithelial Cells Get "Tuft" With Crohn's Disease?

Michael J Rosen  1
Affiliations
Editorial

Could a Small Population of Epithelial Cells Get "Tuft" With Crohn's Disease?

Michael J Rosen. Gastroenterology. 2020 Dec.
No abstract available

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Conflict of interest statement

Conflict of Interest Statement: Dr. Rosen has no relevant financial relationships or conflicts of interests

Figures

Figure 1.
Figure 1.
Tuft cell regulation of the mucosal type 2 immune response and ileitis. (A) Discoveries over the past 4 years have revealed that succinate from protists and luminal microbes, and unknown intermediates from helminths induce rare small intestinal tuft cells to produce IL-25. IL-25 then stimulates ILC2s to produce IL-13, which positively feeds back to the epithelium to induce differentiation of expanded mucus-secreting goblet cell and IL-25-producing tuft cell populations. (B) Banerjee and colleagues demonstrated a paucity of tuft cells in the inflamed ileum from human Crohn’s disease and murine ileitis. Succinate treatment ameliorated murine ileitis in a tuft-cell dependent manner in association with an increase in type 2 immune cell types (ILC2s and Th2 cells) and the type 2 cytokine IL-13, and parallel decrease in type 17 immune cells (ILC3s and Th17 cells) and the type-17-inducing cytokine IL-23.
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References

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